Hemispherical Stokes polarimeter for early cancer diagnosis

Paul Lemaillet, Jessica C. Ramella-Roman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Optimal treatment of skin cancer before it reaches metastasis depends critically on early diagnosis of the melanoma. Valuable information for this diagnosis can be obtained from the analysis of skin roughness. This information can aid in determining the necessity for skin removal. For this purpose, we developed a hemispherical imaging Stokes polarimeter designed to monitor skin cancer based on a roughness assessment of the epidermis. Our setup is composed of 16 out-of-plane polarized light illuminations tubes that contain a three color LED and a vertical polarizer, a Stokes polarimeter that contains 2 liquid crystal retarders, a reference vertical polarizer and a fast acquisition camera. The Stokes polarimeter was calibrated using a set of well-known input polarization states. Each illumination polarizer was positioned using a roughness gold standard and a facet model describing the principal angle of polarization of the analyzed light as a function of the angle of incidence. A set of phantoms mimicking the optical properties of skin at 633 nm as well as skin roughness was built using wax as the bulk material, titanium dioxide as the scatterer and a black dye as the absorber. Images of these phantoms are presented and they are analyzed using a facet model.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7883
DOIs
StatePublished - 2011
Externally publishedYes
EventPhotonic Therapeutics and Diagnostics VII - San Francisco, CA, United States
Duration: Jan 22 2011Jan 24 2011

Other

OtherPhotonic Therapeutics and Diagnostics VII
CountryUnited States
CitySan Francisco, CA
Period1/22/111/24/11

Fingerprint

Polarimeters
polarimeters
Early Detection of Cancer
Skin
roughness
polarizers
cancer
Skin Neoplasms
Surface roughness
Lighting
flat surfaces
illumination
Light
Liquid Crystals
epidermis
retarders
waxes
Waxes
metastasis
polarization

Keywords

  • optical property
  • polarimetry
  • rough surface scattering

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Lemaillet, P., & Ramella-Roman, J. C. (2011). Hemispherical Stokes polarimeter for early cancer diagnosis. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7883). [788304] https://doi.org/10.1117/12.873608

Hemispherical Stokes polarimeter for early cancer diagnosis. / Lemaillet, Paul; Ramella-Roman, Jessica C.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7883 2011. 788304.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lemaillet, P & Ramella-Roman, JC 2011, Hemispherical Stokes polarimeter for early cancer diagnosis. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7883, 788304, Photonic Therapeutics and Diagnostics VII, San Francisco, CA, United States, 1/22/11. https://doi.org/10.1117/12.873608
Lemaillet P, Ramella-Roman JC. Hemispherical Stokes polarimeter for early cancer diagnosis. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7883. 2011. 788304 https://doi.org/10.1117/12.873608
Lemaillet, Paul ; Ramella-Roman, Jessica C. / Hemispherical Stokes polarimeter for early cancer diagnosis. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7883 2011.
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