Hemiplegic migraine: Hyperperfusion and abortive therapy with intravenous verapamil

David A. Hsu, Carl E. Stafstrom, Howard A. Rowley, Jane E. Kiff, Douglas A. Dulli

Research output: Contribution to journalArticlepeer-review


A 20-year-old female with hemiplegic migraine was treated during an acute attack with intravenous verapamil, which reproducibly resolved the headache within 20 min but did not affect her hemiplegia. Magnetic resonance (MR) and computed tomographic (CT) angiography and perfusion performed during the attack showed vasodilation and hyperperfusion. Cerebral hyperperfusion concurrent with hemiplegia suggests a dissociation between cerebral perfusion and neuronal function in hemiplegic migraine. The beneficial effect of verapamil on headache but not hemiplegia suggests a distinct mechanism for pain and neuronal dysfunction in hemiplegic migraine, with the beneficial effect on pain not due to vasodilation.

Original languageEnglish (US)
Pages (from-to)86-90
Number of pages5
JournalBrain and Development
Issue number1
StatePublished - Jan 2008
Externally publishedYes


  • Cerebral perfusion
  • Hemiplegic migraine
  • Intravenous verapamil

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

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