Hematotoxicity in workers exposed to low levels of benzene

Qing Lan, Luoping Zhang, Guilan Li, Roel Vermeulen, Rona S. Weinberg, Mustafa Dosemeci, Stephen M. Rappaport, Min Shen, Blanche P. Alter, Yongji Wu, William Kopp, Suramya Waidyanatha, Charles Rabkin, Weihong Guo, Stephen Chanock, Richard B. Hayes, Martha Linet, Sungkyoon Kim, Songnian Yin, Nathaniel Rothman & 1 others Martyn T. Smith

Research output: Contribution to journalArticle

Abstract

Benzene is known to have toxic effects on the blood and bone marrow, but its impact at levels below the U.S. occupational standard of 1 part per million (ppm) remains uncertain. In a study of 250 workers exposed to benzene, white blood cell and platelet counts were significantly lower than in 140 controls, even for exposure below 1 ppm in air. Progenitor cell colony formation significantly declined with increasing benzene exposure and was more sensitive to the effects of benzene than was the number of mature blood cells. Two genetic variants in key metabolizing enzymes, myeloperoxidase and NAD(P)H:quinone oxidoreductase, influenced susceptibility to benzene hematotoxicity. Thus, hematotoxicity from exposure to benzene occurred at air levels of 1 ppm or less and may be particularly evident among genetically susceptible subpopulations.

Original languageEnglish (US)
Pages (from-to)1774-1776
Number of pages3
JournalScience
Volume306
Issue number5702
DOIs
StatePublished - Dec 3 2004
Externally publishedYes

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Benzene
Air
Blood Cell Count
Poisons
Platelet Count
Leukocyte Count
NAD
Peroxidase
Oxidoreductases
Stem Cells
Bone Marrow
Enzymes

ASJC Scopus subject areas

  • General

Cite this

Lan, Q., Zhang, L., Li, G., Vermeulen, R., Weinberg, R. S., Dosemeci, M., ... Smith, M. T. (2004). Hematotoxicity in workers exposed to low levels of benzene. Science, 306(5702), 1774-1776. https://doi.org/10.1126/science.1102443

Hematotoxicity in workers exposed to low levels of benzene. / Lan, Qing; Zhang, Luoping; Li, Guilan; Vermeulen, Roel; Weinberg, Rona S.; Dosemeci, Mustafa; Rappaport, Stephen M.; Shen, Min; Alter, Blanche P.; Wu, Yongji; Kopp, William; Waidyanatha, Suramya; Rabkin, Charles; Guo, Weihong; Chanock, Stephen; Hayes, Richard B.; Linet, Martha; Kim, Sungkyoon; Yin, Songnian; Rothman, Nathaniel; Smith, Martyn T.

In: Science, Vol. 306, No. 5702, 03.12.2004, p. 1774-1776.

Research output: Contribution to journalArticle

Lan, Q, Zhang, L, Li, G, Vermeulen, R, Weinberg, RS, Dosemeci, M, Rappaport, SM, Shen, M, Alter, BP, Wu, Y, Kopp, W, Waidyanatha, S, Rabkin, C, Guo, W, Chanock, S, Hayes, RB, Linet, M, Kim, S, Yin, S, Rothman, N & Smith, MT 2004, 'Hematotoxicity in workers exposed to low levels of benzene', Science, vol. 306, no. 5702, pp. 1774-1776. https://doi.org/10.1126/science.1102443
Lan Q, Zhang L, Li G, Vermeulen R, Weinberg RS, Dosemeci M et al. Hematotoxicity in workers exposed to low levels of benzene. Science. 2004 Dec 3;306(5702):1774-1776. https://doi.org/10.1126/science.1102443
Lan, Qing ; Zhang, Luoping ; Li, Guilan ; Vermeulen, Roel ; Weinberg, Rona S. ; Dosemeci, Mustafa ; Rappaport, Stephen M. ; Shen, Min ; Alter, Blanche P. ; Wu, Yongji ; Kopp, William ; Waidyanatha, Suramya ; Rabkin, Charles ; Guo, Weihong ; Chanock, Stephen ; Hayes, Richard B. ; Linet, Martha ; Kim, Sungkyoon ; Yin, Songnian ; Rothman, Nathaniel ; Smith, Martyn T. / Hematotoxicity in workers exposed to low levels of benzene. In: Science. 2004 ; Vol. 306, No. 5702. pp. 1774-1776.
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AU - Dosemeci, Mustafa

AU - Rappaport, Stephen M.

AU - Shen, Min

AU - Alter, Blanche P.

AU - Wu, Yongji

AU - Kopp, William

AU - Waidyanatha, Suramya

AU - Rabkin, Charles

AU - Guo, Weihong

AU - Chanock, Stephen

AU - Hayes, Richard B.

AU - Linet, Martha

AU - Kim, Sungkyoon

AU - Yin, Songnian

AU - Rothman, Nathaniel

AU - Smith, Martyn T.

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