Hematotoxicity in workers exposed to low levels of benzene

Qing Lan; Luoping Zhang; Guilan Li; Roel Vermeulen; Rona S. Weinberg; Mustafa Dosemeci; Stephen M. Rappaport; Min Shen; Blanche P. Alter; Yongji Wu; William Kopp; Suramya Waidyanatha; Charles Rabkin; Weihong Guo; Stephen Chanock; Richard B. Hayes; Martha Linet; Sungkyoon Kim; Songnian Yin; Nathaniel Rothman; Martyn T. Smith

doi:10.1126/science.1102443

Hematotoxicity in workers exposed to low levels of benzene

Qing Lan, Luoping Zhang, Guilan Li, Roel Vermeulen, Rona S. Weinberg, Mustafa Dosemeci, Stephen M. Rappaport, Min Shen, Blanche P. Alter, Yongji Wu, William Kopp, Suramya Waidyanatha, Charles Rabkin, Weihong Guo, Stephen Chanock, Richard B. Hayes, Martha Linet, Sungkyoon Kim, Songnian Yin, Nathaniel RothmanMartyn T. Smith

Research output: Contribution to journal › Article › peer-review

446 Scopus citations

Abstract

Benzene is known to have toxic effects on the blood and bone marrow, but its impact at levels below the U.S. occupational standard of 1 part per million (ppm) remains uncertain. In a study of 250 workers exposed to benzene, white blood cell and platelet counts were significantly lower than in 140 controls, even for exposure below 1 ppm in air. Progenitor cell colony formation significantly declined with increasing benzene exposure and was more sensitive to the effects of benzene than was the number of mature blood cells. Two genetic variants in key metabolizing enzymes, myeloperoxidase and NAD(P)H:quinone oxidoreductase, influenced susceptibility to benzene hematotoxicity. Thus, hematotoxicity from exposure to benzene occurred at air levels of 1 ppm or less and may be particularly evident among genetically susceptible subpopulations.

Original language	English (US)
Pages (from-to)	1774-1776
Number of pages	3
Journal	Science
Volume	306
Issue number	5702
DOIs	https://doi.org/10.1126/science.1102443
State	Published - Dec 3 2004
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1126/science.1102443

Cite this

Lan, Q., Zhang, L., Li, G., Vermeulen, R., Weinberg, R. S., Dosemeci, M., Rappaport, S. M., Shen, M., Alter, B. P., Wu, Y., Kopp, W., Waidyanatha, S., Rabkin, C., Guo, W., Chanock, S., Hayes, R. B., Linet, M., Kim, S., Yin, S., ... Smith, M. T. (2004). Hematotoxicity in workers exposed to low levels of benzene. Science, 306(5702), 1774-1776. https://doi.org/10.1126/science.1102443

Lan, Q, Zhang, L, Li, G, Vermeulen, R, Weinberg, RS, Dosemeci, M, Rappaport, SM, Shen, M, Alter, BP, Wu, Y, Kopp, W, Waidyanatha, S, Rabkin, C, Guo, W, Chanock, S, Hayes, RB, Linet, M, Kim, S, Yin, S, Rothman, N & Smith, MT 2004, 'Hematotoxicity in workers exposed to low levels of benzene', Science, vol. 306, no. 5702, pp. 1774-1776. https://doi.org/10.1126/science.1102443

@article{eb69d3b4e03b405d84825dda9247cfc9,

title = "Hematotoxicity in workers exposed to low levels of benzene",

abstract = "Benzene is known to have toxic effects on the blood and bone marrow, but its impact at levels below the U.S. occupational standard of 1 part per million (ppm) remains uncertain. In a study of 250 workers exposed to benzene, white blood cell and platelet counts were significantly lower than in 140 controls, even for exposure below 1 ppm in air. Progenitor cell colony formation significantly declined with increasing benzene exposure and was more sensitive to the effects of benzene than was the number of mature blood cells. Two genetic variants in key metabolizing enzymes, myeloperoxidase and NAD(P)H:quinone oxidoreductase, influenced susceptibility to benzene hematotoxicity. Thus, hematotoxicity from exposure to benzene occurred at air levels of 1 ppm or less and may be particularly evident among genetically susceptible subpopulations.",

author = "Qing Lan and Luoping Zhang and Guilan Li and Roel Vermeulen and Weinberg, {Rona S.} and Mustafa Dosemeci and Rappaport, {Stephen M.} and Min Shen and Alter, {Blanche P.} and Yongji Wu and William Kopp and Suramya Waidyanatha and Charles Rabkin and Weihong Guo and Stephen Chanock and Hayes, {Richard B.} and Martha Linet and Sungkyoon Kim and Songnian Yin and Nathaniel Rothman and Smith, {Martyn T.}",

year = "2004",

month = dec,

day = "3",

doi = "10.1126/science.1102443",

language = "English (US)",

volume = "306",

pages = "1774--1776",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5702",

}

TY - JOUR

T1 - Hematotoxicity in workers exposed to low levels of benzene

AU - Lan, Qing

AU - Zhang, Luoping

AU - Li, Guilan

AU - Vermeulen, Roel

AU - Weinberg, Rona S.

AU - Dosemeci, Mustafa

AU - Rappaport, Stephen M.

AU - Shen, Min

AU - Alter, Blanche P.

AU - Wu, Yongji

AU - Kopp, William

AU - Waidyanatha, Suramya

AU - Rabkin, Charles

AU - Guo, Weihong

AU - Chanock, Stephen

AU - Hayes, Richard B.

AU - Linet, Martha

AU - Kim, Sungkyoon

AU - Yin, Songnian

AU - Rothman, Nathaniel

AU - Smith, Martyn T.

PY - 2004/12/3

Y1 - 2004/12/3

N2 - Benzene is known to have toxic effects on the blood and bone marrow, but its impact at levels below the U.S. occupational standard of 1 part per million (ppm) remains uncertain. In a study of 250 workers exposed to benzene, white blood cell and platelet counts were significantly lower than in 140 controls, even for exposure below 1 ppm in air. Progenitor cell colony formation significantly declined with increasing benzene exposure and was more sensitive to the effects of benzene than was the number of mature blood cells. Two genetic variants in key metabolizing enzymes, myeloperoxidase and NAD(P)H:quinone oxidoreductase, influenced susceptibility to benzene hematotoxicity. Thus, hematotoxicity from exposure to benzene occurred at air levels of 1 ppm or less and may be particularly evident among genetically susceptible subpopulations.

AB - Benzene is known to have toxic effects on the blood and bone marrow, but its impact at levels below the U.S. occupational standard of 1 part per million (ppm) remains uncertain. In a study of 250 workers exposed to benzene, white blood cell and platelet counts were significantly lower than in 140 controls, even for exposure below 1 ppm in air. Progenitor cell colony formation significantly declined with increasing benzene exposure and was more sensitive to the effects of benzene than was the number of mature blood cells. Two genetic variants in key metabolizing enzymes, myeloperoxidase and NAD(P)H:quinone oxidoreductase, influenced susceptibility to benzene hematotoxicity. Thus, hematotoxicity from exposure to benzene occurred at air levels of 1 ppm or less and may be particularly evident among genetically susceptible subpopulations.

UR - http://www.scopus.com/inward/record.url?scp=10044280326&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10044280326&partnerID=8YFLogxK

U2 - 10.1126/science.1102443

DO - 10.1126/science.1102443

M3 - Article

C2 - 15576619

AN - SCOPUS:10044280326

SN - 0036-8075

VL - 306

SP - 1774

EP - 1776

JO - Science

JF - Science

IS - 5702

ER -

Hematotoxicity in workers exposed to low levels of benzene

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this