Hematopoietic cells as sources for patient-specific iPSCs and disease modeling

Zhaohui Ye, Cyndi F. Liu, Yoon Young Jang

Research output: Contribution to journalArticle

Abstract

In addition to being an attractive source for cell replacement therapy human induced pluripotent stem cells (iPSCs) also have great potential for disease modeling and drug development. During the recent several years cell reprogramming technologies have evolved to generate virus-free and integration-free human iPSCs from easily accessible sources such as patient skin fibroblasts and peripheral blood samples. Hematopoietic cells from umbilical cord blood banks and Epstein Barr virus (EBV) immortalized B lymphocyte repositories represent alternative sources for human genetic materials of diverse backgrounds. Ability to reprogram these banked blood cells to pluripotency and differentiate them into a variety of specialized and functional cell types provides valuable tools for studying underlying mechanisms of a broad range of diseases including rare inherited disorders. Here we describe the recent advances in generating disease specific human iPSCs from these different types of hematopoietic cells and their potential applications in disease modeling and regenerative medicine.

Original languageEnglish (US)
Pages (from-to)2840-2844
Number of pages5
JournalCell cycle (Georgetown, Tex.)
Volume10
Issue number17
DOIs
StatePublished - Sep 1 2011

Fingerprint

Induced Pluripotent Stem Cells
Virus Integration
Blood Banks
Regenerative Medicine
Drug Design
Medical Genetics
Cell- and Tissue-Based Therapy
Rare Diseases
Human Herpesvirus 4
Fetal Blood
Blood Cells
B-Lymphocytes
Fibroblasts
Technology
Skin
Genes

Keywords

  • B lymphocytes
  • Blood
  • Disease modeling
  • Drug testing
  • Hematopoietic differentiation
  • Hepatic differentiation
  • Induced pluripotent stem cells (iPSCs)

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

Cite this

Hematopoietic cells as sources for patient-specific iPSCs and disease modeling. / Ye, Zhaohui; Liu, Cyndi F.; Jang, Yoon Young.

In: Cell cycle (Georgetown, Tex.), Vol. 10, No. 17, 01.09.2011, p. 2840-2844.

Research output: Contribution to journalArticle

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