Hematogenous origin of brain macrophages: A case report

Manuel F. Casanova, Juan C Troncoso, Donald L. Price

Research output: Contribution to journalArticle

Abstract

Del Rio-Hortega believed that phagocytic cells in the CNS arise from microglia; however, recent autoradiographic studies have suggested a hematogenous origin for brain macrophages. To clarify this issue, we studied a young man with acute lymphoblastic leukemia and a peripheral white blood cell count of 22/mm3 who had an embolic brain infarct 2 weeks before he died. Macrophages were scarce within the lesion, suggesting that the principal phagocytic cell is hematogenous.

Original languageEnglish (US)
Pages (from-to)844-847
Number of pages4
JournalNeurology
Volume36
Issue number6
StatePublished - 1986

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Phagocytes
Macrophages
Brain
Microglia
Leukocyte Count
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cells

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Casanova, M. F., Troncoso, J. C., & Price, D. L. (1986). Hematogenous origin of brain macrophages: A case report. Neurology, 36(6), 844-847.

Hematogenous origin of brain macrophages : A case report. / Casanova, Manuel F.; Troncoso, Juan C; Price, Donald L.

In: Neurology, Vol. 36, No. 6, 1986, p. 844-847.

Research output: Contribution to journalArticle

Casanova, MF, Troncoso, JC & Price, DL 1986, 'Hematogenous origin of brain macrophages: A case report', Neurology, vol. 36, no. 6, pp. 844-847.
Casanova, Manuel F. ; Troncoso, Juan C ; Price, Donald L. / Hematogenous origin of brain macrophages : A case report. In: Neurology. 1986 ; Vol. 36, No. 6. pp. 844-847.
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