TY - JOUR
T1 - Helix Stop Signals in Proteins and Peptides
T2 - The Capping Box
AU - Harper, Edwin T.
AU - Rose, George D.
PY - 1993/8/3
Y1 - 1993/8/3
N2 - The α-helix [Pauling, L., Corey, R. B., & Branson, H. R. (1951) Proc. Natl. Acad. Sci. U.S.A. 37, 205–211] is a common motif in both proteins and peptides. Despite intense investigation, predictive understanding of helices is still lacking. A recent hypothesis [Presta, L. G., & Rose, G. D. (1988) Science 240, 1632–1641] proposed that the structural specificity of helices resides, in part, in those residues that flank helix termini. If so, then signals that arrest helix propagation—i.e., helix stop signals—should be found among these flanking residues. Evidence is presented for the existence of one such signal, a reciprocal backbone-side-chain hydrogen-bonding interaction, dubbed the capping box. In proteins, the capping box is found uniquely at helix N-termini. In peptides, the capping box can function as a helix stop signal, as shown in the work of Kallenbach and co-workers.
AB - The α-helix [Pauling, L., Corey, R. B., & Branson, H. R. (1951) Proc. Natl. Acad. Sci. U.S.A. 37, 205–211] is a common motif in both proteins and peptides. Despite intense investigation, predictive understanding of helices is still lacking. A recent hypothesis [Presta, L. G., & Rose, G. D. (1988) Science 240, 1632–1641] proposed that the structural specificity of helices resides, in part, in those residues that flank helix termini. If so, then signals that arrest helix propagation—i.e., helix stop signals—should be found among these flanking residues. Evidence is presented for the existence of one such signal, a reciprocal backbone-side-chain hydrogen-bonding interaction, dubbed the capping box. In proteins, the capping box is found uniquely at helix N-termini. In peptides, the capping box can function as a helix stop signal, as shown in the work of Kallenbach and co-workers.
UR - http://www.scopus.com/inward/record.url?scp=0027204024&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027204024&partnerID=8YFLogxK
U2 - 10.1021/bi00081a001
DO - 10.1021/bi00081a001
M3 - Article
C2 - 8347570
AN - SCOPUS:0027204024
SN - 0006-2960
VL - 32
SP - 7605
EP - 7609
JO - Biochemistry
JF - Biochemistry
IS - 30
ER -