Helicobacter pylori Reinfection Is Common in Peruvian Adults after Antibiotic Eradication Therapy

Giselle Soto, Christian T. Bautista, Daniel E. Roth, Robert H Gilman, Billie Velapatiño, Masako Ogura, Giedrius Dailide, Manuel Razuri, Rina Meza, Uriel Katz, Thomas P. Monath, Douglas E. Berg, David N. Taylor

Research output: Contribution to journalArticle

Abstract

To characterize posttreatment recurrence of Helicobacter pylori in Peru, 192 adults with H. pylori-positive gastric biopsy specimens were monitored by 14C-Urea breath test, after eradication of H. pylori by use of amoxicillin, clarithromycin, and omeprazole. The cumulative risk of recurrence at 18 months was 30.3% (95% confidence interval, 21.4%-39.3%). Randomly amplified polymorphic DNA patterns and DNA sequence data established that, among 28 pairs of H. pylori isolates from pretreatment and recurrent infections, 6 (21%) were genetically similar, suggesting recrudescence of the previous infection, and 22 (79%) were different, suggesting reinfection with a new strain that differed from that involved in the initial infection. Eating mainly outside of the home was a risk factor for infection with a new strain (adjusted relative risk [RR], 5.07), whereas older age was a protective factor (adjusted RR, 0.20). Although an increase in the anti-H. pylori IgG antibody titer corresponded to recurrence, pretreatment and recurrent infections were similar with respect to quantitative culture colony counts and histologic characteristics, suggesting that neither prior eradication nor the memory immune response measurably alters the risk or burden of recurrent infection. Although eradication with antibiotics was successful, the high rate of reinfection suggests that treatment is unlikely to have a lasting public health effect in this setting.

Original languageEnglish (US)
Pages (from-to)1263-1275
Number of pages13
JournalJournal of Infectious Diseases
Volume188
Issue number9
DOIs
StatePublished - Nov 1 2003

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Helicobacter pylori
Anti-Bacterial Agents
Infection
Recurrence
Therapeutics
Peru
Breath Tests
Clarithromycin
Omeprazole
Amoxicillin
Urea
Stomach
Public Health
Eating
Immunoglobulin G
Confidence Intervals
Biopsy
Antibodies
DNA

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Soto, G., Bautista, C. T., Roth, D. E., Gilman, R. H., Velapatiño, B., Ogura, M., ... Taylor, D. N. (2003). Helicobacter pylori Reinfection Is Common in Peruvian Adults after Antibiotic Eradication Therapy. Journal of Infectious Diseases, 188(9), 1263-1275. https://doi.org/10.1086/379046

Helicobacter pylori Reinfection Is Common in Peruvian Adults after Antibiotic Eradication Therapy. / Soto, Giselle; Bautista, Christian T.; Roth, Daniel E.; Gilman, Robert H; Velapatiño, Billie; Ogura, Masako; Dailide, Giedrius; Razuri, Manuel; Meza, Rina; Katz, Uriel; Monath, Thomas P.; Berg, Douglas E.; Taylor, David N.

In: Journal of Infectious Diseases, Vol. 188, No. 9, 01.11.2003, p. 1263-1275.

Research output: Contribution to journalArticle

Soto, G, Bautista, CT, Roth, DE, Gilman, RH, Velapatiño, B, Ogura, M, Dailide, G, Razuri, M, Meza, R, Katz, U, Monath, TP, Berg, DE & Taylor, DN 2003, 'Helicobacter pylori Reinfection Is Common in Peruvian Adults after Antibiotic Eradication Therapy', Journal of Infectious Diseases, vol. 188, no. 9, pp. 1263-1275. https://doi.org/10.1086/379046
Soto, Giselle ; Bautista, Christian T. ; Roth, Daniel E. ; Gilman, Robert H ; Velapatiño, Billie ; Ogura, Masako ; Dailide, Giedrius ; Razuri, Manuel ; Meza, Rina ; Katz, Uriel ; Monath, Thomas P. ; Berg, Douglas E. ; Taylor, David N. / Helicobacter pylori Reinfection Is Common in Peruvian Adults after Antibiotic Eradication Therapy. In: Journal of Infectious Diseases. 2003 ; Vol. 188, No. 9. pp. 1263-1275.
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