Helicobacter pylori protection against reflux esophagitis

Hassan Ashktorab; Omid Entezari; Mehdi Nouraie; Ehsan Dowlati; Wayne Frederick; Alfreda Woods; Edward Lee; Hassan Brim; Duane T. Smoot; Firoozeh Ghadyari; Farin Kamangar; Hadie Razjouyan

doi:10.1007/s10620-012-2349-3

Helicobacter pylori protection against reflux esophagitis

Hassan Ashktorab, Omid Entezari, Mehdi Nouraie, Ehsan Dowlati, Wayne Frederick, Alfreda Woods, Edward Lee, Hassan Brim, Duane T. Smoot, Firoozeh Ghadyari, Farin Kamangar, Hadie Razjouyan

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Background and Aim: Negative association has been reported between presence of Helicobacter pylori and developing gastroesophageal reflux disease (GERD) and its complications. The aim of this study was to determine whether H. pylori (HP) can be protective against GERD in an African American (AA) population. Methods: From 2004 to 2007, we studied 2,020 cases; esophagitis (58), gastritis (1,558), both esophagitis and gastritis (363) and a normal control group (41). We collected their pathology and endoscopy unit reports. HP status was determined based on staining of gastric biopsy. Results: HP data was available for 79 % (1,611) of the cases. The frequency of HP positivity in gastritis patients was 40 % (506), in esophagitis patients 4 % and in normal controls 34 % (11), while HP was positive in 34 % of the patients with both esophagitis and gastritis. After adjusting for effects of age and sex, odds ratio of HP was 0.06 (95 % CI 0.01-0.59; P value = 0.01) for the esophagitis group versus the normal group. Conclusions: Our results show H. pylori has a significant negative association with esophagitis in AAs which may point to a protective role of H. pylori in the pathogenesis of esophagitis. In addition, H. pylori may be the reason for the low GERD complications in AAs.

Original language	English (US)
Pages (from-to)	2924-2928
Number of pages	5
Journal	Digestive diseases and sciences
Volume	57
Issue number	11
DOIs	https://doi.org/10.1007/s10620-012-2349-3
State	Published - Nov 2012
Externally published	Yes

Keywords

African Americans
H. pylori
Reflux esophagitis

ASJC Scopus subject areas

Physiology
Gastroenterology

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10.1007/s10620-012-2349-3

Cite this

@article{92b918e46a7f4d65ab180e9e1ac6bf17,

title = "Helicobacter pylori protection against reflux esophagitis",

abstract = "Background and Aim: Negative association has been reported between presence of Helicobacter pylori and developing gastroesophageal reflux disease (GERD) and its complications. The aim of this study was to determine whether H. pylori (HP) can be protective against GERD in an African American (AA) population. Methods: From 2004 to 2007, we studied 2,020 cases; esophagitis (58), gastritis (1,558), both esophagitis and gastritis (363) and a normal control group (41). We collected their pathology and endoscopy unit reports. HP status was determined based on staining of gastric biopsy. Results: HP data was available for 79 % (1,611) of the cases. The frequency of HP positivity in gastritis patients was 40 % (506), in esophagitis patients 4 % and in normal controls 34 % (11), while HP was positive in 34 % of the patients with both esophagitis and gastritis. After adjusting for effects of age and sex, odds ratio of HP was 0.06 (95 % CI 0.01-0.59; P value = 0.01) for the esophagitis group versus the normal group. Conclusions: Our results show H. pylori has a significant negative association with esophagitis in AAs which may point to a protective role of H. pylori in the pathogenesis of esophagitis. In addition, H. pylori may be the reason for the low GERD complications in AAs.",

keywords = "African Americans, H. pylori, Reflux esophagitis",

author = "Hassan Ashktorab and Omid Entezari and Mehdi Nouraie and Ehsan Dowlati and Wayne Frederick and Alfreda Woods and Edward Lee and Hassan Brim and Smoot, {Duane T.} and Firoozeh Ghadyari and Farin Kamangar and Hadie Razjouyan",

note = "Funding Information: Acknowledgments CA102681 was funded by the National Cancer Institute, NIH, and RCMI, Howard University.",

year = "2012",

month = nov,

doi = "10.1007/s10620-012-2349-3",

language = "English (US)",

volume = "57",

pages = "2924--2928",

journal = "Digestive diseases and sciences",

issn = "0163-2116",

publisher = "Plenum Publishers",

number = "11",

}

TY - JOUR

T1 - Helicobacter pylori protection against reflux esophagitis

AU - Ashktorab, Hassan

AU - Entezari, Omid

AU - Nouraie, Mehdi

AU - Dowlati, Ehsan

AU - Frederick, Wayne

AU - Woods, Alfreda

AU - Lee, Edward

AU - Brim, Hassan

AU - Smoot, Duane T.

AU - Ghadyari, Firoozeh

AU - Kamangar, Farin

AU - Razjouyan, Hadie

N1 - Funding Information: Acknowledgments CA102681 was funded by the National Cancer Institute, NIH, and RCMI, Howard University.

PY - 2012/11

Y1 - 2012/11

N2 - Background and Aim: Negative association has been reported between presence of Helicobacter pylori and developing gastroesophageal reflux disease (GERD) and its complications. The aim of this study was to determine whether H. pylori (HP) can be protective against GERD in an African American (AA) population. Methods: From 2004 to 2007, we studied 2,020 cases; esophagitis (58), gastritis (1,558), both esophagitis and gastritis (363) and a normal control group (41). We collected their pathology and endoscopy unit reports. HP status was determined based on staining of gastric biopsy. Results: HP data was available for 79 % (1,611) of the cases. The frequency of HP positivity in gastritis patients was 40 % (506), in esophagitis patients 4 % and in normal controls 34 % (11), while HP was positive in 34 % of the patients with both esophagitis and gastritis. After adjusting for effects of age and sex, odds ratio of HP was 0.06 (95 % CI 0.01-0.59; P value = 0.01) for the esophagitis group versus the normal group. Conclusions: Our results show H. pylori has a significant negative association with esophagitis in AAs which may point to a protective role of H. pylori in the pathogenesis of esophagitis. In addition, H. pylori may be the reason for the low GERD complications in AAs.

AB - Background and Aim: Negative association has been reported between presence of Helicobacter pylori and developing gastroesophageal reflux disease (GERD) and its complications. The aim of this study was to determine whether H. pylori (HP) can be protective against GERD in an African American (AA) population. Methods: From 2004 to 2007, we studied 2,020 cases; esophagitis (58), gastritis (1,558), both esophagitis and gastritis (363) and a normal control group (41). We collected their pathology and endoscopy unit reports. HP status was determined based on staining of gastric biopsy. Results: HP data was available for 79 % (1,611) of the cases. The frequency of HP positivity in gastritis patients was 40 % (506), in esophagitis patients 4 % and in normal controls 34 % (11), while HP was positive in 34 % of the patients with both esophagitis and gastritis. After adjusting for effects of age and sex, odds ratio of HP was 0.06 (95 % CI 0.01-0.59; P value = 0.01) for the esophagitis group versus the normal group. Conclusions: Our results show H. pylori has a significant negative association with esophagitis in AAs which may point to a protective role of H. pylori in the pathogenesis of esophagitis. In addition, H. pylori may be the reason for the low GERD complications in AAs.

KW - African Americans

KW - H. pylori

KW - Reflux esophagitis

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AN - SCOPUS:84871623511

SN - 0163-2116

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SP - 2924

EP - 2928

JO - Digestive diseases and sciences

JF - Digestive diseases and sciences

IS - 11

ER -

Helicobacter pylori protection against reflux esophagitis

Abstract

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