Helicobacter pylori infection reduces systemic availability of dietary vitamin C

M. Woodward, H. Tunstall-Pedoe, K. McColl

Research output: Contribution to journalArticle

Abstract

Objective: Helicobacter pylori infection is recognized to lower the concentration of vitamin C in gastric juice. The objective of this study was to assess the effect of the infection on the systemic availability of dietary vitamin C. Methods: The study involved 1106 men and women aged 25-74 randomly recruited from the population of north Glasgow. Their H. pylori status, dietary vitamin C intake calculated from a food frequency questionnaire and plasma vitamin C concentration were measured. Correction was made for potential confounding factors such as age sex, smoking and social status. Results: The mean plasma vitamin C concentration in those who were H. pylori-positive was only 65% of that in those classified negative. Although partly explained by differences in age, sex, social class, smoking and vitamin C intake the systemic reduction was observed across almost all sub-groups after stratification. Correction for all these factors still gave a plasma vitamin C level for H. pylori positives which was only 80% of that for negatives (P <0.0001). Conclusions: H. pylori substantially impairs the bioavailability of vitamin C. This, together with the reduced vitamin C intake of H. pylori-positive subjects, markedly reduces the plasma vitamin C level of infected subjects. The reduced circulating levels of vitamin C in H. pylori-infected subjects may contribute to the aetiology of gastric cancer, as well as other diseases associated with antioxidant deficiency.

Original languageEnglish (US)
Pages (from-to)233-237
Number of pages5
JournalEuropean Journal of Gastroenterology and Hepatology
Volume13
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

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Helicobacter Infections
Helicobacter pylori
Ascorbic Acid
Smoking
Gastric Juice
Social Class
Biological Availability
Stomach Neoplasms
Antioxidants
Food

Keywords

  • Bioavailability
  • Diet
  • Helicobacter pylori
  • Vitamin C

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Helicobacter pylori infection reduces systemic availability of dietary vitamin C. / Woodward, M.; Tunstall-Pedoe, H.; McColl, K.

In: European Journal of Gastroenterology and Hepatology, Vol. 13, No. 3, 2001, p. 233-237.

Research output: Contribution to journalArticle

Woodward, M. ; Tunstall-Pedoe, H. ; McColl, K. / Helicobacter pylori infection reduces systemic availability of dietary vitamin C. In: European Journal of Gastroenterology and Hepatology. 2001 ; Vol. 13, No. 3. pp. 233-237.
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