Abstract
Objective: Helicobacter pylori infection is recognized to lower the concentration of vitamin C in gastric juice. The objective of this study was to assess the effect of the infection on the systemic availability of dietary vitamin C. Methods: The study involved 1106 men and women aged 25-74 randomly recruited from the population of north Glasgow. Their H. pylori status, dietary vitamin C intake calculated from a food frequency questionnaire and plasma vitamin C concentration were measured. Correction was made for potential confounding factors such as age sex, smoking and social status. Results: The mean plasma vitamin C concentration in those who were H. pylori-positive was only 65% of that in those classified negative. Although partly explained by differences in age, sex, social class, smoking and vitamin C intake the systemic reduction was observed across almost all sub-groups after stratification. Correction for all these factors still gave a plasma vitamin C level for H. pylori positives which was only 80% of that for negatives (P <0.0001). Conclusions: H. pylori substantially impairs the bioavailability of vitamin C. This, together with the reduced vitamin C intake of H. pylori-positive subjects, markedly reduces the plasma vitamin C level of infected subjects. The reduced circulating levels of vitamin C in H. pylori-infected subjects may contribute to the aetiology of gastric cancer, as well as other diseases associated with antioxidant deficiency.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 233-237 |
| Number of pages | 5 |
| Journal | European Journal of Gastroenterology and Hepatology |
| Volume | 13 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2001 |
| Externally published | Yes |
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Keywords
- Bioavailability
- Diet
- Helicobacter pylori
- Vitamin C
ASJC Scopus subject areas
- Gastroenterology
Cite this
Helicobacter pylori infection reduces systemic availability of dietary vitamin C. / Woodward, M.; Tunstall-Pedoe, H.; McColl, K.
In: European Journal of Gastroenterology and Hepatology, Vol. 13, No. 3, 2001, p. 233-237.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Helicobacter pylori infection reduces systemic availability of dietary vitamin C
AU - Woodward, M.
AU - Tunstall-Pedoe, H.
AU - McColl, K.
PY - 2001
Y1 - 2001
N2 - Objective: Helicobacter pylori infection is recognized to lower the concentration of vitamin C in gastric juice. The objective of this study was to assess the effect of the infection on the systemic availability of dietary vitamin C. Methods: The study involved 1106 men and women aged 25-74 randomly recruited from the population of north Glasgow. Their H. pylori status, dietary vitamin C intake calculated from a food frequency questionnaire and plasma vitamin C concentration were measured. Correction was made for potential confounding factors such as age sex, smoking and social status. Results: The mean plasma vitamin C concentration in those who were H. pylori-positive was only 65% of that in those classified negative. Although partly explained by differences in age, sex, social class, smoking and vitamin C intake the systemic reduction was observed across almost all sub-groups after stratification. Correction for all these factors still gave a plasma vitamin C level for H. pylori positives which was only 80% of that for negatives (P <0.0001). Conclusions: H. pylori substantially impairs the bioavailability of vitamin C. This, together with the reduced vitamin C intake of H. pylori-positive subjects, markedly reduces the plasma vitamin C level of infected subjects. The reduced circulating levels of vitamin C in H. pylori-infected subjects may contribute to the aetiology of gastric cancer, as well as other diseases associated with antioxidant deficiency.
AB - Objective: Helicobacter pylori infection is recognized to lower the concentration of vitamin C in gastric juice. The objective of this study was to assess the effect of the infection on the systemic availability of dietary vitamin C. Methods: The study involved 1106 men and women aged 25-74 randomly recruited from the population of north Glasgow. Their H. pylori status, dietary vitamin C intake calculated from a food frequency questionnaire and plasma vitamin C concentration were measured. Correction was made for potential confounding factors such as age sex, smoking and social status. Results: The mean plasma vitamin C concentration in those who were H. pylori-positive was only 65% of that in those classified negative. Although partly explained by differences in age, sex, social class, smoking and vitamin C intake the systemic reduction was observed across almost all sub-groups after stratification. Correction for all these factors still gave a plasma vitamin C level for H. pylori positives which was only 80% of that for negatives (P <0.0001). Conclusions: H. pylori substantially impairs the bioavailability of vitamin C. This, together with the reduced vitamin C intake of H. pylori-positive subjects, markedly reduces the plasma vitamin C level of infected subjects. The reduced circulating levels of vitamin C in H. pylori-infected subjects may contribute to the aetiology of gastric cancer, as well as other diseases associated with antioxidant deficiency.
KW - Bioavailability
KW - Diet
KW - Helicobacter pylori
KW - Vitamin C
UR - http://www.scopus.com/inward/record.url?scp=0035092303&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035092303&partnerID=8YFLogxK
U2 - 10.1097/00042737-200103000-00003
DO - 10.1097/00042737-200103000-00003
M3 - Article
C2 - 11293441
AN - SCOPUS:0035092303
VL - 13
SP - 233
EP - 237
JO - European Journal of Gastroenterology and Hepatology
JF - European Journal of Gastroenterology and Hepatology
SN - 0954-691X
IS - 3
ER -