TY - JOUR
T1 - Helicobacter pylori infection is associated with severe anemia of pregnancy on Pemba Island, Zanzibar
AU - Farag, Tamer H.
AU - Stoltzfus, Rebecca J.
AU - Khalfan, Sabra S.
AU - Tielsch, James M.
PY - 2007/3
Y1 - 2007/3
N2 - Helicobacter pylori infection has recently been associated with iron deficiency and anemia in developed countries. To determine the association of H. pylori and anemia in a tropical region, we measured hemoglobin concentration (Hb) and H. pylori infection by the 13C urea breath test among 857 pregnant women attending antenatal care clinics. Parasitology, anthropometry, obstetric history, sociodemographic and dietary variables were also assessed. Logistic regression showed an odds ratio of 7.63 (95% confidence interval = 1.73-33.55) for H. pylori infection comparing women with and without severe anemia (Hb < 7 g/dL), controlling for hookworm infection, body mass index and parity, but only among women with a diet low in foods containing heme iron. Infection with H. pylori with low bacterial load was associated with lower Hb concentration while high bacterial load was associated with higher Hb concentration. Further research is needed to establish causality because high worldwide prevalence means that even a small associated risk would be of public health significance.
AB - Helicobacter pylori infection has recently been associated with iron deficiency and anemia in developed countries. To determine the association of H. pylori and anemia in a tropical region, we measured hemoglobin concentration (Hb) and H. pylori infection by the 13C urea breath test among 857 pregnant women attending antenatal care clinics. Parasitology, anthropometry, obstetric history, sociodemographic and dietary variables were also assessed. Logistic regression showed an odds ratio of 7.63 (95% confidence interval = 1.73-33.55) for H. pylori infection comparing women with and without severe anemia (Hb < 7 g/dL), controlling for hookworm infection, body mass index and parity, but only among women with a diet low in foods containing heme iron. Infection with H. pylori with low bacterial load was associated with lower Hb concentration while high bacterial load was associated with higher Hb concentration. Further research is needed to establish causality because high worldwide prevalence means that even a small associated risk would be of public health significance.
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U2 - 10.4269/ajtmh.2007.76.541
DO - 10.4269/ajtmh.2007.76.541
M3 - Article
C2 - 17360881
AN - SCOPUS:34247173550
VL - 76
SP - 541
EP - 548
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
SN - 0002-9637
IS - 3
ER -