TY - JOUR
T1 - Helicobacter pylori IgG antibodies in aqueous humor and serum of subjects with primary open angle and pseudo-exfoliation glaucoma in a South Indian population
AU - Deshpande, Nitin
AU - Lalitha, Prajna
AU - Krishna Das, S. R.
AU - Jethani, Jitendra
AU - Pillai, R. Manju
AU - Robin, Alan
AU - Karthik,
PY - 2008/12/1
Y1 - 2008/12/1
N2 - PURPOSE: A prospective, nonrandomized, comparative study was carried out to investigate levels of anti-Helicobacter pylori-specific IgG antibodies in the aqueous humor and serum of patients with primary open angle glaucoma (POAG), exfoliation syndrome [pseudo-exfoliation glaucoma (PXFG)], and with normotensive cataract patients, who served as controls. METHODS: Aqueous humor was aspirated at the beginning of glaucoma surgery from 50 eyes of 50 patients with POAG, with PXFG and at the beginning of phacoemulsification cataract surgery from controls. Serum samples were obtained. Anti-H. pylori IgG concentration in the aqueous humor and serum was measured by means of enzyme linked immunosorbent assay. RESULTS: Serum analysis of anti-H. pylori IgG antibodies revealed statistically significant difference between POAG and PXFG (52.26±52.51 vs. 25.22±35.27, P=0.01). Also, the difference between POAG and controls was statistically significant (54.05±55.04 vs. 33.83±41.73, P=0.04). However, on comparing PXFG with the control group, the difference was statistically insignificant (P=0.12). The mean concentration of anti-H. pylori IgG antibodies in aqueous humor of patients in POAG and controls were not statistically different (3.93±5.14 vs. 2.65±2.87, respectively, P=0.73). The mean concentration of anti-H. pylori IgG antibodies in aqueous humor of patients in PXFG and controls were not statistically different (8.87±30.25 vs. 2.65±2.87, respectively, P=0.83). There was also no statistical difference of IgG levels between POAG and PXFG (3.93±5.14 vs. 8.87±30.25, respectively, P=0.87). CONCLUSIONS: The levels of anti-H. pylori IgG titers in sera of individuals with POAG were significantly higher compared with PXFG and control groups. We support the hypothesis of the role of anti-H. pylori antibodies in causative mechanism for POAG. We could not find a significant link between the anti-H. pylori IgG antibodies and the PXFG.
AB - PURPOSE: A prospective, nonrandomized, comparative study was carried out to investigate levels of anti-Helicobacter pylori-specific IgG antibodies in the aqueous humor and serum of patients with primary open angle glaucoma (POAG), exfoliation syndrome [pseudo-exfoliation glaucoma (PXFG)], and with normotensive cataract patients, who served as controls. METHODS: Aqueous humor was aspirated at the beginning of glaucoma surgery from 50 eyes of 50 patients with POAG, with PXFG and at the beginning of phacoemulsification cataract surgery from controls. Serum samples were obtained. Anti-H. pylori IgG concentration in the aqueous humor and serum was measured by means of enzyme linked immunosorbent assay. RESULTS: Serum analysis of anti-H. pylori IgG antibodies revealed statistically significant difference between POAG and PXFG (52.26±52.51 vs. 25.22±35.27, P=0.01). Also, the difference between POAG and controls was statistically significant (54.05±55.04 vs. 33.83±41.73, P=0.04). However, on comparing PXFG with the control group, the difference was statistically insignificant (P=0.12). The mean concentration of anti-H. pylori IgG antibodies in aqueous humor of patients in POAG and controls were not statistically different (3.93±5.14 vs. 2.65±2.87, respectively, P=0.73). The mean concentration of anti-H. pylori IgG antibodies in aqueous humor of patients in PXFG and controls were not statistically different (8.87±30.25 vs. 2.65±2.87, respectively, P=0.83). There was also no statistical difference of IgG levels between POAG and PXFG (3.93±5.14 vs. 8.87±30.25, respectively, P=0.87). CONCLUSIONS: The levels of anti-H. pylori IgG titers in sera of individuals with POAG were significantly higher compared with PXFG and control groups. We support the hypothesis of the role of anti-H. pylori antibodies in causative mechanism for POAG. We could not find a significant link between the anti-H. pylori IgG antibodies and the PXFG.
KW - Helicobacter pylori
KW - Primary open angle glaucoma
KW - Pseudo-exfoliation glaucoma
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U2 - 10.1097/IJG.0b013e318166f00b
DO - 10.1097/IJG.0b013e318166f00b
M3 - Article
C2 - 19092454
AN - SCOPUS:60749133595
SN - 1057-0829
VL - 17
SP - 605
EP - 610
JO - Journal of glaucoma
JF - Journal of glaucoma
IS - 8
ER -