Heavy-chain class switch does not terminate somatic mutation

H. Shan, M. Shlomchik, M. Weigert

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


We studied the H-chain class switch rearrangement in four groups of clonally related B cell hybridomas, to test the hypothesis that class switch terminates somatic mutation in a B cell. Using switch region-specific probes in Southern blot analysis individual μ-γ switch rearrangement events can be distinguished. We show that clonally related IgG-producing hybridomas that differ by mutations often share a common switch rearrangement. This indicates that class switch in these cells did not terminate somatic mutation.

Original languageEnglish (US)
Pages (from-to)531-536
Number of pages6
JournalJournal of Experimental Medicine
Issue number2
StatePublished - Aug 1 1990
Externally publishedYes

ASJC Scopus subject areas

  • Immunology


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