Heat shock protein and p53 expression in head and neck squamous cell carcinoma

R. Gandour-Edwards, Bruce Trock, P. Gumerlock, P. J. Donald

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Heat shock proteins have been associated with the mutant form of the tumor suppressor genes, TP53, and with resistance to cancer chemotherapy. METHODS: Archival tissues from 50 patients with head and neck squamous cell carcinoma who received primary surgical resection were examined for p53, HSP27, and HSP70 by immunohistochemistry and correlated with tumor stage, grade, and 5-year survival (alive or deceased). RESULTS: Both heat shock proteins were strongly expressed in normal mucosa and in small (T1 and T2) tumors. Thirty (60%) of tumors were positive for p53, 43 (86%) for HSP27, and 34 (68%) for HSP70, with no association between p53 and heat shock protein expression. Twenty-five patients were alive (4 with disease), and 25 patients were deceased (9 from other causes). p53 Protein overexpression correlated with low-grade tumors. Only primary tumor site (i.e., oral cavity > larynx > oropharynx/base of tongue) and N stage were significantly associated with survival. CONCLUSIONS: Heat shock proteins are expressed in normal upper respiratory tract squamous mucosa, and their role in carcinoma remains unclear. None of the markers, p53, HSP27, or HSP70, demonstrated prognostic significance for 5-year survival. We confirm the recognized association of cervical lymph node metastases with decreased survival.

Original languageEnglish (US)
Pages (from-to)610-615
Number of pages6
JournalOtolaryngology - Head and Neck Surgery
Volume118
Issue number5
DOIs
StatePublished - 1998
Externally publishedYes

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Heat-Shock Proteins
Neoplasms
Survival
Mucous Membrane
Oropharynx
Larynx
Tumor Suppressor Genes
Tongue
Respiratory System
Mouth
Carcinoma, squamous cell of head and neck
Lymph Nodes
Immunohistochemistry
Neoplasm Metastasis
Carcinoma
Drug Therapy
Proteins

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Heat shock protein and p53 expression in head and neck squamous cell carcinoma. / Gandour-Edwards, R.; Trock, Bruce; Gumerlock, P.; Donald, P. J.

In: Otolaryngology - Head and Neck Surgery, Vol. 118, No. 5, 1998, p. 610-615.

Research output: Contribution to journalArticle

Gandour-Edwards, R. ; Trock, Bruce ; Gumerlock, P. ; Donald, P. J. / Heat shock protein and p53 expression in head and neck squamous cell carcinoma. In: Otolaryngology - Head and Neck Surgery. 1998 ; Vol. 118, No. 5. pp. 610-615.
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AB - BACKGROUND: Heat shock proteins have been associated with the mutant form of the tumor suppressor genes, TP53, and with resistance to cancer chemotherapy. METHODS: Archival tissues from 50 patients with head and neck squamous cell carcinoma who received primary surgical resection were examined for p53, HSP27, and HSP70 by immunohistochemistry and correlated with tumor stage, grade, and 5-year survival (alive or deceased). RESULTS: Both heat shock proteins were strongly expressed in normal mucosa and in small (T1 and T2) tumors. Thirty (60%) of tumors were positive for p53, 43 (86%) for HSP27, and 34 (68%) for HSP70, with no association between p53 and heat shock protein expression. Twenty-five patients were alive (4 with disease), and 25 patients were deceased (9 from other causes). p53 Protein overexpression correlated with low-grade tumors. Only primary tumor site (i.e., oral cavity > larynx > oropharynx/base of tongue) and N stage were significantly associated with survival. CONCLUSIONS: Heat shock proteins are expressed in normal upper respiratory tract squamous mucosa, and their role in carcinoma remains unclear. None of the markers, p53, HSP27, or HSP70, demonstrated prognostic significance for 5-year survival. We confirm the recognized association of cervical lymph node metastases with decreased survival.

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