Heat-denatured human immunodeficiency virus type 1 protein 24 antigen: Prognostic value in adults with early-stage disease

Timothy R. Sterling, Donald R. Hoover, Jacquie Astemborski, David Vlahov, John Bartlett, Jorg Schupbach

Research output: Contribution to journalArticle

Abstract

CD4+ lymphocyte count and human immunodeficiency virus (HIV) type 1 RNA level are useful for determining when to initiate antiretroviral therapy but are not used widely in developing countries due to the high cost. Heat-denatured protein 24 (p24) antigen is an inexpensive assay that predicts disease progression among persons with advanced disease but has not been assessed among persons with early-stage disease. Plasma levels of heat-denatured p24 antigen were quantified in baseline study-visit specimens obtained from injection drug users enrolled in a longitudinal cohort study of HIV-1 infection. Of the 494 study participants (median initial CD4+ lymphocyte count, 518 lymphocytes/mm3), 90 (18%) progressed to acquired immunodeficiency syndrome within 5 years. p24 antigen level correlated with both CD4+ lymphocyte count (r = -0.34; P<.0001) and HIV-1 RNA level (r = 0.55; P<.0001). p24 antigen level >5 pg/mL predicted disease progression, comparable with that of cutoff CD4+ lymphocyte count 3 and HIV-1 RNA level >30,000 copies/mL. Heat-denatured p24 antigen level predicted subsequent clinical disease progression in early-stage HIV-1 infection and correlated with both CD4+ lymphocyte count and HIV-1 RNA level.

Original languageEnglish (US)
Pages (from-to)1181-1185
Number of pages5
JournalJournal of Infectious Diseases
Volume186
Issue number8
DOIs
StatePublished - Oct 15 2002

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Human Immunodeficiency Virus Proteins
CD4 Lymphocyte Count
HIV-1
Hot Temperature
Antigens
Disease Progression
Virus Diseases
RNA
Proteins
Drug Users
Developing Countries
Longitudinal Studies
Acquired Immunodeficiency Syndrome
Cohort Studies
Lymphocytes
Costs and Cost Analysis
Injections

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Heat-denatured human immunodeficiency virus type 1 protein 24 antigen : Prognostic value in adults with early-stage disease. / Sterling, Timothy R.; Hoover, Donald R.; Astemborski, Jacquie; Vlahov, David; Bartlett, John; Schupbach, Jorg.

In: Journal of Infectious Diseases, Vol. 186, No. 8, 15.10.2002, p. 1181-1185.

Research output: Contribution to journalArticle

Sterling, Timothy R. ; Hoover, Donald R. ; Astemborski, Jacquie ; Vlahov, David ; Bartlett, John ; Schupbach, Jorg. / Heat-denatured human immunodeficiency virus type 1 protein 24 antigen : Prognostic value in adults with early-stage disease. In: Journal of Infectious Diseases. 2002 ; Vol. 186, No. 8. pp. 1181-1185.
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