Heart Rate Recovery and Cancer Risk: Prospective Cohort Study

Yong Hyun Byun; Sang Yeun Kim; Yejin Mok; Youngwon Kim; Sun Ha Jee

doi:10.1177/1010539517745630

Heart Rate Recovery and Cancer Risk: Prospective Cohort Study

Yong Hyun Byun, Sang Yeun Kim, Yejin Mok, Youngwon Kim, Sun Ha Jee

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

This study aims to determine the association between 2-minute heart rate recovery (HRR) and cancer risk. Each participant (5379 women; 8485 men) provided HRR obtained from treadmill tests. The outcome was site-specific cancer. Over 9 years of follow-up, 630 cancer events (258 women) were accrued. Slower HRR was associated with increased thyroid cancer risk in women (P for trend =.0121) and colorectal cancer risk in men (P for trend =.0034). The lowest HRR (<13 bpm) had higher hazards of thyroid cancer (hazard ratio [HR] = 2.20; 95% CI = 1.28-3.77) in women and colorectal cancer (HR = 3.08; 95% CI = 1.32-7.15) in men. In women, slower HRR and lower proportions of heart rate recovery (PHRR) were associated with higher hazards of thyroid cancer in women and metabolically related cancers (liver and colorectal) in men. Slower HRR and lower PHRR were independent risk factors for thyroid cancer in women and metabolically related cancers in men.

Original language	English (US)
Pages (from-to)	45-55
Number of pages	11
Journal	Asia-Pacific Journal of Public Health
Volume	30
Issue number	1
DOIs	https://doi.org/10.1177/1010539517745630
State	Published - Jan 1 2018

Keywords

cancer
cohort study
exercise treadmill test
heart rate recovery

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

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10.1177/1010539517745630

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title = "Heart Rate Recovery and Cancer Risk: Prospective Cohort Study",

abstract = "This study aims to determine the association between 2-minute heart rate recovery (HRR) and cancer risk. Each participant (5379 women; 8485 men) provided HRR obtained from treadmill tests. The outcome was site-specific cancer. Over 9 years of follow-up, 630 cancer events (258 women) were accrued. Slower HRR was associated with increased thyroid cancer risk in women (P for trend =.0121) and colorectal cancer risk in men (P for trend =.0034). The lowest HRR (<13 bpm) had higher hazards of thyroid cancer (hazard ratio [HR] = 2.20; 95% CI = 1.28-3.77) in women and colorectal cancer (HR = 3.08; 95% CI = 1.32-7.15) in men. In women, slower HRR and lower proportions of heart rate recovery (PHRR) were associated with higher hazards of thyroid cancer in women and metabolically related cancers (liver and colorectal) in men. Slower HRR and lower PHRR were independent risk factors for thyroid cancer in women and metabolically related cancers in men.",

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author = "Byun, {Yong Hyun} and Kim, {Sang Yeun} and Yejin Mok and Youngwon Kim and Jee, {Sun Ha}",

note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by a grant from the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (1631020). The results of the study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation. Publisher Copyright: {\textcopyright} 2017, {\textcopyright} 2017 APJPH.",

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N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by a grant from the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (1631020). The results of the study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation. Publisher Copyright: © 2017, © 2017 APJPH.

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N2 - This study aims to determine the association between 2-minute heart rate recovery (HRR) and cancer risk. Each participant (5379 women; 8485 men) provided HRR obtained from treadmill tests. The outcome was site-specific cancer. Over 9 years of follow-up, 630 cancer events (258 women) were accrued. Slower HRR was associated with increased thyroid cancer risk in women (P for trend =.0121) and colorectal cancer risk in men (P for trend =.0034). The lowest HRR (<13 bpm) had higher hazards of thyroid cancer (hazard ratio [HR] = 2.20; 95% CI = 1.28-3.77) in women and colorectal cancer (HR = 3.08; 95% CI = 1.32-7.15) in men. In women, slower HRR and lower proportions of heart rate recovery (PHRR) were associated with higher hazards of thyroid cancer in women and metabolically related cancers (liver and colorectal) in men. Slower HRR and lower PHRR were independent risk factors for thyroid cancer in women and metabolically related cancers in men.

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Heart Rate Recovery and Cancer Risk: Prospective Cohort Study

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Keywords

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