Heart rate power spectrum and plasma catecholamine levels after postural change and cold pressor test

Brahm Goldstein, Paul D. Woolf, Donna Deking, David J. Delong, Christopher Cox, Mark H. Kempski

Research output: Contribution to journalArticle

Abstract

During stress, low-frequency (0.01-0.15 Hz) heart rate power and plasma catecholamine levels increase in response to increased sympathetic efferent activity. To test the hypothesis that low-frequency heart rate power, a measure of sympathetic control of heart rate, directly correlates with plasma catecholamine concentrations during periods of increased sympathetic tone, we compared heart rate power spectral measures with antecubital vein norepinephrine, epinephrine, and dopamine concentrations during postural change and after cold pressor testing. We analyzed absolute levels and changes in mean heart rate, respiratory rate, blood pressure, heart rate power spectra, and concentration of norepinephrine, epinephrine, and dopamine in 14 healthy volunteers (seven female/seven male) after postural change and in six (three female/three male) during cold pressor testing. Postural change from supine to standing position resulted in increased heart rate [61 ± 8 versus 83+11 (SD) bpm, p <0.05], diastolic (68 ± 7 versus 11 ± 6 mm Hg, p <0.05) and mean blood pressures (84 ± 6 versus 91 ± 9 mm Hg, p <0.05), norepinephrine concentration (2.09 ± 1.11 versus 3.23 ± 1.62 nmol/L, p <0.05), and low-frequency heart rate power (7.55 ± 5.63 versus 33.79 ± 23.55 bpm2, p <0.05). High-frequency heart rate power, a measure of parasympathetic control of heart rate, decreased with standing (5.38 ± 4.22 versus 2.94 ± 2.69 bpm2, p <0.05). Diastolic (66 ± 7 versus 81 ± 9 mm Hg, p <0.05) and mean (83 ± 9 versus 97 ± 11 mm Hg, p <0.05) blood pressures and norepinephrine concentration (1.21 ± 0.40 versus 1.77 ± 0.79 nmol/L, p <0.05) increased with cold pressor testing. We found no correlation between absolute levels or changes in low-frequency heart rate power and norepinephrine, epinephrine, or dopamine concentration. Thus, we conclude that low-frequency heart rate power and plasma catecholamines are significantly affected by physiologic changes but arc likely regulated by different areas within the sympathetic nervous system.

Original languageEnglish (US)
Pages (from-to)358-363
Number of pages6
JournalPediatric Research
Volume36
Issue number3
StatePublished - 1994
Externally publishedYes

Fingerprint

Catecholamines
Heart Rate
Norepinephrine
Epinephrine
Dopamine
Blood Pressure
Sympathetic Nervous System
Respiratory Rate
Posture
Veins
Healthy Volunteers

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Goldstein, B., Woolf, P. D., Deking, D., Delong, D. J., Cox, C., & Kempski, M. H. (1994). Heart rate power spectrum and plasma catecholamine levels after postural change and cold pressor test. Pediatric Research, 36(3), 358-363.

Heart rate power spectrum and plasma catecholamine levels after postural change and cold pressor test. / Goldstein, Brahm; Woolf, Paul D.; Deking, Donna; Delong, David J.; Cox, Christopher; Kempski, Mark H.

In: Pediatric Research, Vol. 36, No. 3, 1994, p. 358-363.

Research output: Contribution to journalArticle

Goldstein, B, Woolf, PD, Deking, D, Delong, DJ, Cox, C & Kempski, MH 1994, 'Heart rate power spectrum and plasma catecholamine levels after postural change and cold pressor test', Pediatric Research, vol. 36, no. 3, pp. 358-363.
Goldstein, Brahm ; Woolf, Paul D. ; Deking, Donna ; Delong, David J. ; Cox, Christopher ; Kempski, Mark H. / Heart rate power spectrum and plasma catecholamine levels after postural change and cold pressor test. In: Pediatric Research. 1994 ; Vol. 36, No. 3. pp. 358-363.
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abstract = "During stress, low-frequency (0.01-0.15 Hz) heart rate power and plasma catecholamine levels increase in response to increased sympathetic efferent activity. To test the hypothesis that low-frequency heart rate power, a measure of sympathetic control of heart rate, directly correlates with plasma catecholamine concentrations during periods of increased sympathetic tone, we compared heart rate power spectral measures with antecubital vein norepinephrine, epinephrine, and dopamine concentrations during postural change and after cold pressor testing. We analyzed absolute levels and changes in mean heart rate, respiratory rate, blood pressure, heart rate power spectra, and concentration of norepinephrine, epinephrine, and dopamine in 14 healthy volunteers (seven female/seven male) after postural change and in six (three female/three male) during cold pressor testing. Postural change from supine to standing position resulted in increased heart rate [61 ± 8 versus 83+11 (SD) bpm, p <0.05], diastolic (68 ± 7 versus 11 ± 6 mm Hg, p <0.05) and mean blood pressures (84 ± 6 versus 91 ± 9 mm Hg, p <0.05), norepinephrine concentration (2.09 ± 1.11 versus 3.23 ± 1.62 nmol/L, p <0.05), and low-frequency heart rate power (7.55 ± 5.63 versus 33.79 ± 23.55 bpm2, p <0.05). High-frequency heart rate power, a measure of parasympathetic control of heart rate, decreased with standing (5.38 ± 4.22 versus 2.94 ± 2.69 bpm2, p <0.05). Diastolic (66 ± 7 versus 81 ± 9 mm Hg, p <0.05) and mean (83 ± 9 versus 97 ± 11 mm Hg, p <0.05) blood pressures and norepinephrine concentration (1.21 ± 0.40 versus 1.77 ± 0.79 nmol/L, p <0.05) increased with cold pressor testing. We found no correlation between absolute levels or changes in low-frequency heart rate power and norepinephrine, epinephrine, or dopamine concentration. Thus, we conclude that low-frequency heart rate power and plasma catecholamines are significantly affected by physiologic changes but arc likely regulated by different areas within the sympathetic nervous system.",
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AU - Cox, Christopher

AU - Kempski, Mark H.

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N2 - During stress, low-frequency (0.01-0.15 Hz) heart rate power and plasma catecholamine levels increase in response to increased sympathetic efferent activity. To test the hypothesis that low-frequency heart rate power, a measure of sympathetic control of heart rate, directly correlates with plasma catecholamine concentrations during periods of increased sympathetic tone, we compared heart rate power spectral measures with antecubital vein norepinephrine, epinephrine, and dopamine concentrations during postural change and after cold pressor testing. We analyzed absolute levels and changes in mean heart rate, respiratory rate, blood pressure, heart rate power spectra, and concentration of norepinephrine, epinephrine, and dopamine in 14 healthy volunteers (seven female/seven male) after postural change and in six (three female/three male) during cold pressor testing. Postural change from supine to standing position resulted in increased heart rate [61 ± 8 versus 83+11 (SD) bpm, p <0.05], diastolic (68 ± 7 versus 11 ± 6 mm Hg, p <0.05) and mean blood pressures (84 ± 6 versus 91 ± 9 mm Hg, p <0.05), norepinephrine concentration (2.09 ± 1.11 versus 3.23 ± 1.62 nmol/L, p <0.05), and low-frequency heart rate power (7.55 ± 5.63 versus 33.79 ± 23.55 bpm2, p <0.05). High-frequency heart rate power, a measure of parasympathetic control of heart rate, decreased with standing (5.38 ± 4.22 versus 2.94 ± 2.69 bpm2, p <0.05). Diastolic (66 ± 7 versus 81 ± 9 mm Hg, p <0.05) and mean (83 ± 9 versus 97 ± 11 mm Hg, p <0.05) blood pressures and norepinephrine concentration (1.21 ± 0.40 versus 1.77 ± 0.79 nmol/L, p <0.05) increased with cold pressor testing. We found no correlation between absolute levels or changes in low-frequency heart rate power and norepinephrine, epinephrine, or dopamine concentration. Thus, we conclude that low-frequency heart rate power and plasma catecholamines are significantly affected by physiologic changes but arc likely regulated by different areas within the sympathetic nervous system.

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