Heart rate and blood pressure variability in children with chronic kidney disease: A report from the CKiD study

Gina Marie Barletta, Joseph Flynn, Mark Mitsnefes, Joshua Samuels, Lisa Aronson Friedman, Derek Ng, Christopher Cox, Timothy Poffenbarger, Bradley Warady, Susan Furth

Research output: Contribution to journalArticle

Abstract

Background: Autonomic nervous system dysfunction and sympathetic nervous system over-activity play important roles in the development of hypertension associated with chronic kidney disease (CKD). In adults, increased blood pressure variability (BPV) appears to be directly related to sympathetic over-activity with increased risk of end-organ damage and cardiovascular events. Decreased heart rate variability (HRV) has been observed in adults with CKD, and is an independent predictor of mortality. Methods: The purpose of this study was to evaluate BPV and HRV in pediatric patients enrolled in the Chronic Kidney Disease in Children Study. Ambulatory blood pressure monitoring data were available for analysis of 215 person-visits from 144 children that were not receiving antihypertensive medications. Results: BPV and HRV were determined by standard deviation and coefficient of variation for heart rate and systolic and diastolic blood pressure for each patient averaged for wake/sleep periods during 24-h monitoring. Uniformly lower values were displayed during sleep versus wake periods: BPV was 20 % lower during sleep (p

Original languageEnglish (US)
Pages (from-to)1059-1065
Number of pages7
JournalPediatric Nephrology
Volume29
Issue number6
DOIs
StatePublished - 2014

Fingerprint

Chronic Renal Insufficiency
Heart Rate
Blood Pressure
Sleep
Ambulatory Blood Pressure Monitoring
Autonomic Nervous System
Sympathetic Nervous System
Antihypertensive Agents
Pediatrics
Hypertension
Mortality

Keywords

  • Blood pressure variability
  • Chronic kidney disease
  • Heart rate variability
  • Hypertension
  • Pediatrics

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Cite this

Heart rate and blood pressure variability in children with chronic kidney disease : A report from the CKiD study. / Barletta, Gina Marie; Flynn, Joseph; Mitsnefes, Mark; Samuels, Joshua; Friedman, Lisa Aronson; Ng, Derek; Cox, Christopher; Poffenbarger, Timothy; Warady, Bradley; Furth, Susan.

In: Pediatric Nephrology, Vol. 29, No. 6, 2014, p. 1059-1065.

Research output: Contribution to journalArticle

Barletta, GM, Flynn, J, Mitsnefes, M, Samuels, J, Friedman, LA, Ng, D, Cox, C, Poffenbarger, T, Warady, B & Furth, S 2014, 'Heart rate and blood pressure variability in children with chronic kidney disease: A report from the CKiD study', Pediatric Nephrology, vol. 29, no. 6, pp. 1059-1065. https://doi.org/10.1007/s00467-013-2737-8
Barletta, Gina Marie ; Flynn, Joseph ; Mitsnefes, Mark ; Samuels, Joshua ; Friedman, Lisa Aronson ; Ng, Derek ; Cox, Christopher ; Poffenbarger, Timothy ; Warady, Bradley ; Furth, Susan. / Heart rate and blood pressure variability in children with chronic kidney disease : A report from the CKiD study. In: Pediatric Nephrology. 2014 ; Vol. 29, No. 6. pp. 1059-1065.
@article{98163db3ac3d4d44bd26b8e17a9f5c42,
title = "Heart rate and blood pressure variability in children with chronic kidney disease: A report from the CKiD study",
abstract = "Background: Autonomic nervous system dysfunction and sympathetic nervous system over-activity play important roles in the development of hypertension associated with chronic kidney disease (CKD). In adults, increased blood pressure variability (BPV) appears to be directly related to sympathetic over-activity with increased risk of end-organ damage and cardiovascular events. Decreased heart rate variability (HRV) has been observed in adults with CKD, and is an independent predictor of mortality. Methods: The purpose of this study was to evaluate BPV and HRV in pediatric patients enrolled in the Chronic Kidney Disease in Children Study. Ambulatory blood pressure monitoring data were available for analysis of 215 person-visits from 144 children that were not receiving antihypertensive medications. Results: BPV and HRV were determined by standard deviation and coefficient of variation for heart rate and systolic and diastolic blood pressure for each patient averaged for wake/sleep periods during 24-h monitoring. Uniformly lower values were displayed during sleep versus wake periods: BPV was 20 {\%} lower during sleep (p",
keywords = "Blood pressure variability, Chronic kidney disease, Heart rate variability, Hypertension, Pediatrics",
author = "Barletta, {Gina Marie} and Joseph Flynn and Mark Mitsnefes and Joshua Samuels and Friedman, {Lisa Aronson} and Derek Ng and Christopher Cox and Timothy Poffenbarger and Bradley Warady and Susan Furth",
year = "2014",
doi = "10.1007/s00467-013-2737-8",
language = "English (US)",
volume = "29",
pages = "1059--1065",
journal = "Pediatric Nephrology",
issn = "0931-041X",
publisher = "Springer Verlag",
number = "6",

}

TY - JOUR

T1 - Heart rate and blood pressure variability in children with chronic kidney disease

T2 - A report from the CKiD study

AU - Barletta, Gina Marie

AU - Flynn, Joseph

AU - Mitsnefes, Mark

AU - Samuels, Joshua

AU - Friedman, Lisa Aronson

AU - Ng, Derek

AU - Cox, Christopher

AU - Poffenbarger, Timothy

AU - Warady, Bradley

AU - Furth, Susan

PY - 2014

Y1 - 2014

N2 - Background: Autonomic nervous system dysfunction and sympathetic nervous system over-activity play important roles in the development of hypertension associated with chronic kidney disease (CKD). In adults, increased blood pressure variability (BPV) appears to be directly related to sympathetic over-activity with increased risk of end-organ damage and cardiovascular events. Decreased heart rate variability (HRV) has been observed in adults with CKD, and is an independent predictor of mortality. Methods: The purpose of this study was to evaluate BPV and HRV in pediatric patients enrolled in the Chronic Kidney Disease in Children Study. Ambulatory blood pressure monitoring data were available for analysis of 215 person-visits from 144 children that were not receiving antihypertensive medications. Results: BPV and HRV were determined by standard deviation and coefficient of variation for heart rate and systolic and diastolic blood pressure for each patient averaged for wake/sleep periods during 24-h monitoring. Uniformly lower values were displayed during sleep versus wake periods: BPV was 20 % lower during sleep (p

AB - Background: Autonomic nervous system dysfunction and sympathetic nervous system over-activity play important roles in the development of hypertension associated with chronic kidney disease (CKD). In adults, increased blood pressure variability (BPV) appears to be directly related to sympathetic over-activity with increased risk of end-organ damage and cardiovascular events. Decreased heart rate variability (HRV) has been observed in adults with CKD, and is an independent predictor of mortality. Methods: The purpose of this study was to evaluate BPV and HRV in pediatric patients enrolled in the Chronic Kidney Disease in Children Study. Ambulatory blood pressure monitoring data were available for analysis of 215 person-visits from 144 children that were not receiving antihypertensive medications. Results: BPV and HRV were determined by standard deviation and coefficient of variation for heart rate and systolic and diastolic blood pressure for each patient averaged for wake/sleep periods during 24-h monitoring. Uniformly lower values were displayed during sleep versus wake periods: BPV was 20 % lower during sleep (p

KW - Blood pressure variability

KW - Chronic kidney disease

KW - Heart rate variability

KW - Hypertension

KW - Pediatrics

UR - http://www.scopus.com/inward/record.url?scp=84901604675&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901604675&partnerID=8YFLogxK

U2 - 10.1007/s00467-013-2737-8

DO - 10.1007/s00467-013-2737-8

M3 - Article

C2 - 24488505

AN - SCOPUS:84901604675

VL - 29

SP - 1059

EP - 1065

JO - Pediatric Nephrology

JF - Pediatric Nephrology

SN - 0931-041X

IS - 6

ER -