Heart Failure With Preserved Ejection Fraction Expert Panel Report: Current Controversies and Implications for Clinical Trials

Kishan S. Parikh, Kavita Sharma, Mona Fiuzat, Howard K. Surks, Jyothis T. George, Narimon Honarpour, Christopher Depre, Patrice Desvigne-Nickens, Richard Nkulikiyinka, Gregory D. Lewis, Mardi Gomberg-Maitland, Christopher M. O'Connor, Norman Stockbridge, Robert M. Califf, Marvin A. Konstam, James L. Januzzi, Scott D. Solomon, Barry A. Borlaug, Sanjiv J. Shah, Margaret M. RedfieldG. Michael Felker

Research output: Contribution to journalReview articlepeer-review

Abstract

The number of persons with heart failure has continued to rise over the last several years. Approximately one-half of those living with heart failure have heart failure with preserved ejection fraction, but critical unsolved questions remain across the spectrum of basic, translational, clinical, and population research in heart failure with preserved ejection fraction. In this study, the authors summarize existing knowledge, persistent controversies, and gaps in evidence with regard to the understanding of heart failure with preserved ejection fraction. Our analysis is based on an expert panel discussion “Think Tank” meeting that included representatives from academia, the National Institutes of Health, the U.S. Food and Drug Administration, the Centers for Medicare & Medicaid Services, and industry.

Original languageEnglish (US)
Pages (from-to)619-632
Number of pages14
JournalJACC: Heart Failure
Volume6
Issue number8
DOIs
StatePublished - Aug 2018

Keywords

  • classification scheme
  • diagnosis
  • diastolic
  • ejection fraction
  • endpoints
  • heart failure
  • pathophysiology
  • preserved ejection fraction
  • pulmonary hypertension
  • subject eligibility
  • treatment

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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