Heart failure, myocardial stunning, and troponin: a key regulator of the cardiac myofilament.

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Abstract

This review discusses post-translational modifications of myofilament regulatory proteins, particularly troponin, associated with heart failure and myocardial stunning--two common disease processes. Altered phosphorylation, partial proteolysis and, possibly, oxidative damage to myofilament proteins may result in abnormalities in both systolic and diastolic function. At a molecular level, these changes may lead to abnormalities in crossbridge cycling and tension development and result in inefficiencies in utilization of energy. Understanding these alterations may lead to new targeted therapies.

Original languageEnglish (US)
JournalCongestive heart failure (Greenwich, Conn.)
Volume12
Issue number1
Publication statusPublished - Jan 2006

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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