TY - JOUR
T1 - Heart-Brain Axis
T2 - Effects of Neurologic Injury on Cardiovascular Function
AU - Tahsili-Fahadan, Pouya
AU - Geocadin, Romergryko G.
N1 - Publisher Copyright:
© 2017 American Heart Association, Inc.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2017/2/3
Y1 - 2017/2/3
N2 - A complex interaction exists between the nervous and cardiovascular systems. A large network of cortical and subcortical brain regions control cardiovascular function via the sympathetic and parasympathetic outflow. A dysfunction in one system may lead to changes in the function of the other. The effects of cardiovascular disease on the nervous system have been widely studied; however, our understanding of the effects of neurological disorders on the cardiovascular system has only expanded in the past 2 decades. Various pathologies of the nervous system can lead to a wide range of alterations in function and structure of the cardiovascular system ranging from transient and benign electrographic changes to myocardial injury, cardiomyopathy, and even cardiac death. In this article, we first review the anatomy and physiology of the central and autonomic nervous systems in regard to control of the cardiovascular function. The effects of neurological injury on cardiac function and structure will be summarized, and finally, we review neurological disorders commonly associated with cardiovascular manifestations.
AB - A complex interaction exists between the nervous and cardiovascular systems. A large network of cortical and subcortical brain regions control cardiovascular function via the sympathetic and parasympathetic outflow. A dysfunction in one system may lead to changes in the function of the other. The effects of cardiovascular disease on the nervous system have been widely studied; however, our understanding of the effects of neurological disorders on the cardiovascular system has only expanded in the past 2 decades. Various pathologies of the nervous system can lead to a wide range of alterations in function and structure of the cardiovascular system ranging from transient and benign electrographic changes to myocardial injury, cardiomyopathy, and even cardiac death. In this article, we first review the anatomy and physiology of the central and autonomic nervous systems in regard to control of the cardiovascular function. The effects of neurological injury on cardiac function and structure will be summarized, and finally, we review neurological disorders commonly associated with cardiovascular manifestations.
KW - arrhythmias
KW - autonomic nervous system
KW - cardiomyopathy
KW - cerebrovascular disease
KW - stroke
KW - sudden cardiac death
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U2 - 10.1161/CIRCRESAHA.116.308446
DO - 10.1161/CIRCRESAHA.116.308446
M3 - Review article
C2 - 28154104
AN - SCOPUS:85011841755
SN - 0009-7330
VL - 120
SP - 559
EP - 572
JO - Circulation research
JF - Circulation research
IS - 3
ER -