Heart and systemic effects of statin pretreatment in a rat model of abdominal sepsis. Assessment by Tc99m-sestamibi biodistribition

Robson Macedo, Mehrbod Som Som Javadi, Takahiro Higuchi, Marília Daniela Ferreira De Carvalho, Vanessa De Fátima Lima Paiva Medeiros, Ítalo Medeiros Azevedo, Francisco Pignataro Lima, Aldo Cunha Medeiros

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate the heart and the Tc-99m-sestamibi biodistribution after statin pretreatment in a rat model of abdominal sepsis. Methods: Twenty-four Wistar rats were randomly distributed into four groups (n=6 per group): 1) sepsis with simvastatin treatment, 2) sepsis with vehicle, 3) sham control with simvastatin and 4) sham control with vehicle. 24 hours after cecal ligation and puncture rats received 1.0MBq of Tc-99m–sestamibi i.v. 30min after, animals were euthanized for ex-vivo tissue counting and myocardium histological analysis. Results: Myocardial histologic alterations were not detected 24 hours post-sepsis. There was significantly increased cardiac Tc-99m-sestamibi activity in the sepsis group with simvastatin treatment (1.9±0.3%ID/g, p

Original languageEnglish (US)
Pages (from-to)388-393
Number of pages6
JournalActa Cirurgica Brasileira
Volume30
Issue number6
DOIs
StatePublished - Jun 30 2015

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Sepsis
Simvastatin
Punctures
Ligation
Wistar Rats
Myocardium
Therapeutics

Keywords

  • Heart
  • Inflammation
  • Rats
  • Sepsis
  • Simvastatin
  • Technetium Tc 99m Sestamibi

ASJC Scopus subject areas

  • Surgery

Cite this

Macedo, R., Javadi, M. S. S., Higuchi, T., De Carvalho, M. D. F., De Fátima Lima Paiva Medeiros, V., Azevedo, Í. M., ... Medeiros, A. C. (2015). Heart and systemic effects of statin pretreatment in a rat model of abdominal sepsis. Assessment by Tc99m-sestamibi biodistribition. Acta Cirurgica Brasileira, 30(6), 388-393. https://doi.org/10.1590/S0102-865020150060000003

Heart and systemic effects of statin pretreatment in a rat model of abdominal sepsis. Assessment by Tc99m-sestamibi biodistribition. / Macedo, Robson; Javadi, Mehrbod Som Som; Higuchi, Takahiro; De Carvalho, Marília Daniela Ferreira; De Fátima Lima Paiva Medeiros, Vanessa; Azevedo, Ítalo Medeiros; Lima, Francisco Pignataro; Medeiros, Aldo Cunha.

In: Acta Cirurgica Brasileira, Vol. 30, No. 6, 30.06.2015, p. 388-393.

Research output: Contribution to journalArticle

Macedo, R, Javadi, MSS, Higuchi, T, De Carvalho, MDF, De Fátima Lima Paiva Medeiros, V, Azevedo, ÍM, Lima, FP & Medeiros, AC 2015, 'Heart and systemic effects of statin pretreatment in a rat model of abdominal sepsis. Assessment by Tc99m-sestamibi biodistribition', Acta Cirurgica Brasileira, vol. 30, no. 6, pp. 388-393. https://doi.org/10.1590/S0102-865020150060000003
Macedo, Robson ; Javadi, Mehrbod Som Som ; Higuchi, Takahiro ; De Carvalho, Marília Daniela Ferreira ; De Fátima Lima Paiva Medeiros, Vanessa ; Azevedo, Ítalo Medeiros ; Lima, Francisco Pignataro ; Medeiros, Aldo Cunha. / Heart and systemic effects of statin pretreatment in a rat model of abdominal sepsis. Assessment by Tc99m-sestamibi biodistribition. In: Acta Cirurgica Brasileira. 2015 ; Vol. 30, No. 6. pp. 388-393.
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