Hearing loss and incident dementia

Frank R. Lin, E. J. Metter, Richard J. O'Brien, Susan M. Resnick, Alan B. Zonderman, Luigi Ferrucci

Research output: Contribution to journalArticle

Abstract

Objective: To determine whether hearing loss is associated with incident all-cause dementia and Alzheimer disease (AD). Design: Prospective study of 639 individuals who underwent audiometric testing and were dementia free in 1990 to 1994. Hearing loss was defined by a pure-tone average of hearing thresholds at 0.5, 1, 2, and 4 kHz in the better-hearing ear (normal, 70 dB [n=6]). Diagnosis of incident dementia was made by consensus diagnostic conference. Cox proportional hazards models were used to model time to incident dementia according to severity of hearing loss and were adjusted for age, sex, race, education, diabetes mellitus, smoking, and hypertension. Setting: Baltimore Longitudinal Study of Aging. Participants: Six hundred thirty-nine individuals aged 36 to 90 years. Main Outcome Measure: Incident caces of all-cause dementia and AD until May 31, 2008. Results: During a median follow-up of 11.9 years, 58 cases of incident all-cause dementia were diagnosed, of which 37 cases were AD. The risk of incident all-cause dementia increased log linearly with the severity of baseline hearing loss (1.27 per 10-dB loss; 95% confidence interval, 1.06-1.50). Compared with normal hearing, the hazard ratio (95% confidence interval) for incident all-cause dementia was 1.89 (1.00-3.58) for mild hearing loss, 3.00 (1.43-6.30) for moderate hearing loss, and 4.94 (1.09-22.40) for severe hearing loss. The risk of incident AD also increased with baseline hearing loss (1.20 per 10 dB of hearing loss) but with a wider confidence interval (0.94-1.53). Conclusions: Hearing loss is independently associated with incident all-cause dementia. Whether hearing loss is a marker for early-stage dementia or is actually a modifiable risk factor for dementia deserves further study.

Original languageEnglish (US)
Pages (from-to)214-220
Number of pages7
JournalArchives of Neurology
Volume68
Issue number2
DOIs
StatePublished - Feb 2011

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Dementia
Hearing loss
Hearing Loss
Causes
Alzheimer Disease
Alzheimer's disease
Hearing
Confidence Intervals
Confidence interval
Hazard
Baltimore
Sex Education
Proportional Hazards Models
Ear
Longitudinal Studies
Diabetes Mellitus
Smoking
Outcome Assessment (Health Care)
Prospective Studies
Hypertension

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Lin, F. R., Metter, E. J., O'Brien, R. J., Resnick, S. M., Zonderman, A. B., & Ferrucci, L. (2011). Hearing loss and incident dementia. Archives of Neurology, 68(2), 214-220. DOI: 10.1001/archneurol.2010.362

Hearing loss and incident dementia. / Lin, Frank R.; Metter, E. J.; O'Brien, Richard J.; Resnick, Susan M.; Zonderman, Alan B.; Ferrucci, Luigi.

In: Archives of Neurology, Vol. 68, No. 2, 02.2011, p. 214-220.

Research output: Contribution to journalArticle

Lin, FR, Metter, EJ, O'Brien, RJ, Resnick, SM, Zonderman, AB & Ferrucci, L 2011, 'Hearing loss and incident dementia' Archives of Neurology, vol 68, no. 2, pp. 214-220. DOI: 10.1001/archneurol.2010.362
Lin FR, Metter EJ, O'Brien RJ, Resnick SM, Zonderman AB, Ferrucci L. Hearing loss and incident dementia. Archives of Neurology. 2011 Feb;68(2):214-220. Available from, DOI: 10.1001/archneurol.2010.362

Lin, Frank R.; Metter, E. J.; O'Brien, Richard J.; Resnick, Susan M.; Zonderman, Alan B.; Ferrucci, Luigi / Hearing loss and incident dementia.

In: Archives of Neurology, Vol. 68, No. 2, 02.2011, p. 214-220.

Research output: Contribution to journalArticle

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