Health-related quality of life in adolescent patients with hepatitis C genotype 1 treated with Sofosbuvir and Ledipasvir

Zobair M. Younossi, Maria Stepanova, William Balistreri, Kathleen Schwarz, Karen F. Murray, Philip Rosenthal, Sanjay Bansal, Sharon Hunt

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Objective: The aim of the study was to assess the effect of treatment with ledipasvir/sofosbuvir (LDV/SOF) on the health-related quality of life (HRQL) of pediatric patients with chronic hepatitis C virus (HCV) infection. Methods: Adolescents (12-17 years) with HCV were treated with LDV/SOF (90/400mgdaily) for12weeks.HRQLwasassessedusingthePedsQLv4.0-SF15 completed by the children and caregivers before, during, and after treatment. Results: We included 100 adolescents with HCV genotype 1 infection (14.7±2.0 years, 1% known cirrhosis, 80% treatment-naïve, 97% sustained virologic response-12). At baseline, HRQL the caregiver- perceived HRQL scores were lower than adolescents' self-reported scores (by 6.7-7.9 points, all P<0.01). At the end of 12 weeks of treatment, however, the caregiver-reported HRQL scores showed a significant improvement (+all P<0.04), whereas the adolescents' self-reported scores did not change fromthe baseline.HRQLscores reported by caregivers remained higher than baseline (by+4.7-+7.5, P<0.01) through 12weeks after treatment, as did the adolescents' self-reportedEmotional Functioning scores (+4.3 from baseline, P=0.0009); observed improvements were sustained after 24 weeks of follow-up (all P<0.04).Multivariate analysis showed that, after adjustment for location, age, and sex, having a history of anxiety and panic disorders were consistent predictors of impaired HRQL in adolescents with HCV infection (P<0.05). Conclusions: Treatment of HCV in adolescents with LDV/SOF is associated with some improvement in HRQL. Caregivers' reports of HRQL in adolescents with HCV significantly increased with treatment and were similar to the adolescent self-reported HRQL after sustained virologic response-12.

Original languageEnglish (US)
Pages (from-to)112-116
Number of pages5
JournalJournal of pediatric gastroenterology and nutrition
Volume66
Issue number1
DOIs
StatePublished - Jan 1 2018

Keywords

  • Interferon
  • Pediatric patients
  • Quality of life
  • Ribavirin
  • School functioning

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

Fingerprint

Dive into the research topics of 'Health-related quality of life in adolescent patients with hepatitis C genotype 1 treated with Sofosbuvir and Ledipasvir'. Together they form a unique fingerprint.

Cite this