Health-related quality of life before and after head and neck squamous cell carcinoma

Analysis of the Surveillance, Epidemiology, and End Results-Medicare Health Outcomes Survey linkage

Research output: Contribution to journalArticle

Abstract

BACKGROUND Understanding health-related quality of life (HRQOL) is crucial to providing high-quality survivorship care for patients with head and neck squamous cell carcinoma (HNSCC). Trends in and prognostic significance of HRQOL before and after HNSCC have not been well described. METHODS HRQOL for older individuals with HNSCC was examined using the linked Surveillance, Epidemiology, and End Results-Medicare Health Outcomes Survey database. Surveys assessing HRQOL from 5 years prediagnosis to 10 years postdiagnosis were included. HRQOL over time was modeled using multilevel linear regression with restricted cubic splines and was reported as either total HRQOL or change in HRQOL (denoted Δ). The association of prediagnosis HRQOL with survival was examined. RESULTS In total, 1653 individuals were included; of these, 61% completed 1 survey, and 39% completed multiple surveys. Overall HRQOL decreased progressively until 13 months postdiagnosis, then recovered toward baseline between 2 and 5 years. However, after stratification by survival group, the postdiagnosis recovery was not observed. Individuals with shorter survival had lower HRQOL prediagnosis ( 5-year survivors, 96.4; P =.004) with a steeper decline in HRQOL during diagnosis and treatment ( 5-year survivors: Δ, -0.9; 95% CI, -1.8, 0.08). Radiotherapy and advanced stage were associated with greater declines in HRQOL during diagnosis and treatment (P

Original languageEnglish (US)
Pages (from-to)1861-1870
Number of pages10
JournalCancer
Volume122
Issue number12
DOIs
StatePublished - Jun 15 2016

Fingerprint

Medicare
Health Surveys
Epidemiology
Quality of Life
Survival
Survivors
Carcinoma, squamous cell of head and neck
Quality of Health Care
Linear Models
Radiotherapy
Survival Rate
Databases

Keywords

  • head and neck cancer
  • oropharynx
  • quality of life
  • radiotherapy
  • survival

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

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title = "Health-related quality of life before and after head and neck squamous cell carcinoma: Analysis of the Surveillance, Epidemiology, and End Results-Medicare Health Outcomes Survey linkage",
abstract = "BACKGROUND Understanding health-related quality of life (HRQOL) is crucial to providing high-quality survivorship care for patients with head and neck squamous cell carcinoma (HNSCC). Trends in and prognostic significance of HRQOL before and after HNSCC have not been well described. METHODS HRQOL for older individuals with HNSCC was examined using the linked Surveillance, Epidemiology, and End Results-Medicare Health Outcomes Survey database. Surveys assessing HRQOL from 5 years prediagnosis to 10 years postdiagnosis were included. HRQOL over time was modeled using multilevel linear regression with restricted cubic splines and was reported as either total HRQOL or change in HRQOL (denoted Δ). The association of prediagnosis HRQOL with survival was examined. RESULTS In total, 1653 individuals were included; of these, 61{\%} completed 1 survey, and 39{\%} completed multiple surveys. Overall HRQOL decreased progressively until 13 months postdiagnosis, then recovered toward baseline between 2 and 5 years. However, after stratification by survival group, the postdiagnosis recovery was not observed. Individuals with shorter survival had lower HRQOL prediagnosis ( 5-year survivors, 96.4; P =.004) with a steeper decline in HRQOL during diagnosis and treatment ( 5-year survivors: Δ, -0.9; 95{\%} CI, -1.8, 0.08). Radiotherapy and advanced stage were associated with greater declines in HRQOL during diagnosis and treatment (P",
keywords = "head and neck cancer, oropharynx, quality of life, radiotherapy, survival",
author = "Rettig, {Eleni M.} and Gypsyamber D'Souza and Carol Thompson and Koch, {Wayne Martin} and Eisele, {David W} and Carole Fakhry",
year = "2016",
month = "6",
day = "15",
doi = "10.1002/cncr.30005",
language = "English (US)",
volume = "122",
pages = "1861--1870",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
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T1 - Health-related quality of life before and after head and neck squamous cell carcinoma

T2 - Analysis of the Surveillance, Epidemiology, and End Results-Medicare Health Outcomes Survey linkage

AU - Rettig, Eleni M.

AU - D'Souza, Gypsyamber

AU - Thompson, Carol

AU - Koch, Wayne Martin

AU - Eisele, David W

AU - Fakhry, Carole

PY - 2016/6/15

Y1 - 2016/6/15

N2 - BACKGROUND Understanding health-related quality of life (HRQOL) is crucial to providing high-quality survivorship care for patients with head and neck squamous cell carcinoma (HNSCC). Trends in and prognostic significance of HRQOL before and after HNSCC have not been well described. METHODS HRQOL for older individuals with HNSCC was examined using the linked Surveillance, Epidemiology, and End Results-Medicare Health Outcomes Survey database. Surveys assessing HRQOL from 5 years prediagnosis to 10 years postdiagnosis were included. HRQOL over time was modeled using multilevel linear regression with restricted cubic splines and was reported as either total HRQOL or change in HRQOL (denoted Δ). The association of prediagnosis HRQOL with survival was examined. RESULTS In total, 1653 individuals were included; of these, 61% completed 1 survey, and 39% completed multiple surveys. Overall HRQOL decreased progressively until 13 months postdiagnosis, then recovered toward baseline between 2 and 5 years. However, after stratification by survival group, the postdiagnosis recovery was not observed. Individuals with shorter survival had lower HRQOL prediagnosis ( 5-year survivors, 96.4; P =.004) with a steeper decline in HRQOL during diagnosis and treatment ( 5-year survivors: Δ, -0.9; 95% CI, -1.8, 0.08). Radiotherapy and advanced stage were associated with greater declines in HRQOL during diagnosis and treatment (P

AB - BACKGROUND Understanding health-related quality of life (HRQOL) is crucial to providing high-quality survivorship care for patients with head and neck squamous cell carcinoma (HNSCC). Trends in and prognostic significance of HRQOL before and after HNSCC have not been well described. METHODS HRQOL for older individuals with HNSCC was examined using the linked Surveillance, Epidemiology, and End Results-Medicare Health Outcomes Survey database. Surveys assessing HRQOL from 5 years prediagnosis to 10 years postdiagnosis were included. HRQOL over time was modeled using multilevel linear regression with restricted cubic splines and was reported as either total HRQOL or change in HRQOL (denoted Δ). The association of prediagnosis HRQOL with survival was examined. RESULTS In total, 1653 individuals were included; of these, 61% completed 1 survey, and 39% completed multiple surveys. Overall HRQOL decreased progressively until 13 months postdiagnosis, then recovered toward baseline between 2 and 5 years. However, after stratification by survival group, the postdiagnosis recovery was not observed. Individuals with shorter survival had lower HRQOL prediagnosis ( 5-year survivors, 96.4; P =.004) with a steeper decline in HRQOL during diagnosis and treatment ( 5-year survivors: Δ, -0.9; 95% CI, -1.8, 0.08). Radiotherapy and advanced stage were associated with greater declines in HRQOL during diagnosis and treatment (P

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