Health-related quality of life among people with HIV disease: Results from the multicenter AIDS cohort study

E. G. Bing; R. D. Hays; L. P. Jacobson; B. Chen; S. J. Gange; N. E. Kass; J. S. Chmiel; S. L. Zucconi

doi:10.1023/A:1008919227665

Health-related quality of life among people with HIV disease: Results from the multicenter AIDS cohort study

E. G. Bing, R. D. Hays, L. P. Jacobson, B. Chen, S. J. Gange, N. E. Kass, J. S. Chmiel, S. L. Zucconi

Research output: Contribution to journal › Article › peer-review

128 Scopus citations

Abstract

To examine the effect of HIV status, symptomatology and CD4 + lymphocyte level on health-related quality of life, the Medical Outcomes Study Short-Form Health Survey (SF-36) was administered to 2,295 gay men enrolled in the Multicenter AIDS Cohort Study (MACS) in 1994. Distinct physical and mental health factors of the SF-36 were found. Seropositive asymptomatic individuals and seropositive individuals with CD4 + lymphocytes ≥ 500/mm³ scored as well as seronegative participants on all of the mental health domain scales, but lower on the general health perceptions and physical health composite score. Seropositive individuals with at least one symptom or with CD4 + lymphocytes below 200/mm³ scored significantly lower on all of the SF-36 scales and summary scores than seronegative controls. The SF-36 was found to exhibit similar mental and physical health factors for an adult gay male population to that previously seen in general population samples and in patient groups with other diseases. In conclusion, HIV-positive men who are asymptomatic or have CD4 + lymphocytes above 500/mm³ have similar perceived mental health but worse perceived physical health than seronegative men. HIV-positive men who are symptomatic or have CD4 + lymphocytes below 200/mm³ have worse perceived mental and physical health than seronegative men.

Original language	English (US)
Pages (from-to)	55-63
Number of pages	9
Journal	Quality of Life Research
Volume	9
Issue number	1
DOIs	https://doi.org/10.1023/A:1008919227665
State	Published - 2000

Keywords

Acquired immune deficiency syndrome (AIDS) factor analysis
Functional status
Health status
Health status indicators
Human immunodeficiency virus (HIV)
Mental health
Quality of life

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

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10.1023/A:1008919227665

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@article{19995fef146d4c7786180dc60e050511,

title = "Health-related quality of life among people with HIV disease: Results from the multicenter AIDS cohort study",

abstract = "To examine the effect of HIV status, symptomatology and CD4 + lymphocyte level on health-related quality of life, the Medical Outcomes Study Short-Form Health Survey (SF-36) was administered to 2,295 gay men enrolled in the Multicenter AIDS Cohort Study (MACS) in 1994. Distinct physical and mental health factors of the SF-36 were found. Seropositive asymptomatic individuals and seropositive individuals with CD4 + lymphocytes ≥ 500/mm3 scored as well as seronegative participants on all of the mental health domain scales, but lower on the general health perceptions and physical health composite score. Seropositive individuals with at least one symptom or with CD4 + lymphocytes below 200/mm3 scored significantly lower on all of the SF-36 scales and summary scores than seronegative controls. The SF-36 was found to exhibit similar mental and physical health factors for an adult gay male population to that previously seen in general population samples and in patient groups with other diseases. In conclusion, HIV-positive men who are asymptomatic or have CD4 + lymphocytes above 500/mm3 have similar perceived mental health but worse perceived physical health than seronegative men. HIV-positive men who are symptomatic or have CD4 + lymphocytes below 200/mm3 have worse perceived mental and physical health than seronegative men.",

keywords = "Acquired immune deficiency syndrome (AIDS) factor analysis, Functional status, Health status, Health status indicators, Human immunodeficiency virus (HIV), Mental health, Quality of life",

author = "Bing, {E. G.} and Hays, {R. D.} and Jacobson, {L. P.} and B. Chen and Gange, {S. J.} and Kass, {N. E.} and Chmiel, {J. S.} and Zucconi, {S. L.}",

note = "Funding Information: Data in this manuscript were collected by the Multicenter AIDS Cohort Study (MACS) with centers (Principal Investigators) at The Johns Hopkins School of Public Health (Joseph Mar-golick, Alvaro Mun{\"A} oz); Howard Brown Health Center and Northwestern University Medical School (John Phair); University of California, Los Angeles (Roger Detels, Janis V. Giorgi); and University of Pittsburgh (Charles Rinaldo). The MACS is funded by the National Institute of Allergy and Infectious Diseases, with additional supplemental funding from the National Cancer Institute: UO1-AI-35042, 5-M01-RR-00052 (GCRC), UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, UO1-AI-35041. Dr. Bing received additional support from the National Institute of Mental Health (MH-94-197), the NIMH Center for HIV Identification, Prevention, and Treatment Services (P30MH-58-107) and the NIMH Faculty Training Program in Mental Health Services Research (MH-00-990). The authors would like to thank Ellen Lazarus, Jonathan Kei, Lucilia Ortiz-Barron, and Eric Miller for their diligent assistance on this project.",

year = "2000",

doi = "10.1023/A:1008919227665",

language = "English (US)",

volume = "9",

pages = "55--63",

journal = "Quality of Life Research",

issn = "0962-9343",

publisher = "Springer Netherlands",

number = "1",

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TY - JOUR

T1 - Health-related quality of life among people with HIV disease

T2 - Results from the multicenter AIDS cohort study

AU - Bing, E. G.

AU - Hays, R. D.

AU - Jacobson, L. P.

AU - Chen, B.

AU - Gange, S. J.

AU - Kass, N. E.

AU - Chmiel, J. S.

AU - Zucconi, S. L.

N1 - Funding Information: Data in this manuscript were collected by the Multicenter AIDS Cohort Study (MACS) with centers (Principal Investigators) at The Johns Hopkins School of Public Health (Joseph Mar-golick, Alvaro MunÄ oz); Howard Brown Health Center and Northwestern University Medical School (John Phair); University of California, Los Angeles (Roger Detels, Janis V. Giorgi); and University of Pittsburgh (Charles Rinaldo). The MACS is funded by the National Institute of Allergy and Infectious Diseases, with additional supplemental funding from the National Cancer Institute: UO1-AI-35042, 5-M01-RR-00052 (GCRC), UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, UO1-AI-35041. Dr. Bing received additional support from the National Institute of Mental Health (MH-94-197), the NIMH Center for HIV Identification, Prevention, and Treatment Services (P30MH-58-107) and the NIMH Faculty Training Program in Mental Health Services Research (MH-00-990). The authors would like to thank Ellen Lazarus, Jonathan Kei, Lucilia Ortiz-Barron, and Eric Miller for their diligent assistance on this project.

PY - 2000

Y1 - 2000

N2 - To examine the effect of HIV status, symptomatology and CD4 + lymphocyte level on health-related quality of life, the Medical Outcomes Study Short-Form Health Survey (SF-36) was administered to 2,295 gay men enrolled in the Multicenter AIDS Cohort Study (MACS) in 1994. Distinct physical and mental health factors of the SF-36 were found. Seropositive asymptomatic individuals and seropositive individuals with CD4 + lymphocytes ≥ 500/mm3 scored as well as seronegative participants on all of the mental health domain scales, but lower on the general health perceptions and physical health composite score. Seropositive individuals with at least one symptom or with CD4 + lymphocytes below 200/mm3 scored significantly lower on all of the SF-36 scales and summary scores than seronegative controls. The SF-36 was found to exhibit similar mental and physical health factors for an adult gay male population to that previously seen in general population samples and in patient groups with other diseases. In conclusion, HIV-positive men who are asymptomatic or have CD4 + lymphocytes above 500/mm3 have similar perceived mental health but worse perceived physical health than seronegative men. HIV-positive men who are symptomatic or have CD4 + lymphocytes below 200/mm3 have worse perceived mental and physical health than seronegative men.

AB - To examine the effect of HIV status, symptomatology and CD4 + lymphocyte level on health-related quality of life, the Medical Outcomes Study Short-Form Health Survey (SF-36) was administered to 2,295 gay men enrolled in the Multicenter AIDS Cohort Study (MACS) in 1994. Distinct physical and mental health factors of the SF-36 were found. Seropositive asymptomatic individuals and seropositive individuals with CD4 + lymphocytes ≥ 500/mm3 scored as well as seronegative participants on all of the mental health domain scales, but lower on the general health perceptions and physical health composite score. Seropositive individuals with at least one symptom or with CD4 + lymphocytes below 200/mm3 scored significantly lower on all of the SF-36 scales and summary scores than seronegative controls. The SF-36 was found to exhibit similar mental and physical health factors for an adult gay male population to that previously seen in general population samples and in patient groups with other diseases. In conclusion, HIV-positive men who are asymptomatic or have CD4 + lymphocytes above 500/mm3 have similar perceived mental health but worse perceived physical health than seronegative men. HIV-positive men who are symptomatic or have CD4 + lymphocytes below 200/mm3 have worse perceived mental and physical health than seronegative men.

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KW - Health status

KW - Health status indicators

KW - Human immunodeficiency virus (HIV)

KW - Mental health

KW - Quality of life

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Health-related quality of life among people with HIV disease: Results from the multicenter AIDS cohort study

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Keywords

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