La qualité de vie des patients co-infectés par le VIH et le VHC

Translated title of the contribution: Health related quality of life among HIV-HCV co-infected patients

M. Préau, C. Protopopescu, B. Spire, P. Dellamonica, I. Poizot-Martin, V. Villes, M. P. Carrieri, C. Boirot, A. D. Bouhnik, M. P. Carrieri, J. P. Cassuto, M. Chesney, P. Dellamonica, P. Dujardin, H. Gallais, J. A. Gastaut, G. Lepeu, C. Marimoutou, D. Mechali, J. P. MoattiJ. Moreau, M. Nègre, Y. Obadia, I. Poizot-Martin, C. Pradier, M. Préau, D. Rey, C. Rouzioux, A. Sobel, B. Spire, F. Trémolières, V. Villes, D. Vlahov

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: To assess factors associated with higher levels of health-related quality-of-life among HIV-HCV co-infected injecting drug users and more specifically, to explore the role of injecting drug status and drug maintenance treatment on health-related quality-of-life. Methods: The two hundred and forty participants were patients enrolled in the MANIF cohort of HIV-HCV patients infected through injecting drug use who completed a self-administered question-naire that included a health-related quality-of-life evaluation at the 42 month follow-up. A self-administered questionnaire collected information about socio-demographic characteristics, health-related quality-of-life (as measured by SF-12), injecting drug status and drug maintenance treatment, depressive symptoms, self-reported symptoms related to HIV treatment; clinical characteristics were obtained from medical records. Results: Higher levels of both mental and physical health-related quality-of-life were found in patients with no depressive symptoms, abstinent from drugs and experiencing few drug related problems. Patients on drug maintenance treatment who stopped injecting drugs had better mental health-related quality-of-life than injectors but lower levels of mental health-related quality-of-life than abstinent patients. Mental health-related quality-of-life was also independently higher in patients receiving high social support. Physical health-related quality-of-life was independently higher for patients who stopped injection, whether on drug maintenance treatment or not, for patients on antiretroviral treatment and for patients who remained in clinical stage A. Conclusions: Drug maintenance treatment seems to be associated with higher health-related quality-of-life among patients HIV-HCV co-infected by drug use, but it is still necessary to help patients cope with the mental impact of drug cessation. These results underline the need to provide regular psychological support and counselling for HIV-HCV co-infected injecting drug users during the medical follow-up for HIV-disease.

Translated title of the contributionHealth related quality of life among HIV-HCV co-infected patients
Original languageFrench
Pages (from-to)1S33-1S43
JournalRevue d'Epidemiologie et de Sante Publique
Issue numberHS1
StatePublished - Jul 2006
Externally publishedYes


  • Drug maintenance treatment
  • HIV-HCV positive
  • Health-related quality-of-life
  • Injecting drug users
  • Injection status

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health


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