Health outcomes of neonates with osteogenesis imperfecta: a cross-sectional study

Doris P. Yimgang, Evelise Brizola, Jay Shapiro

Research output: Contribution to journalArticle

Abstract

Objective: To assess at-birth health outcomes of neonates with osteogenesis imperfecta (OI). Study design: A total of 53 women who self-reported having had at least one child with OI completed the survey. We evaluated pregnancy length, neonatal intensive care unit (NICU) usage, at-birth complications, and the child’s clinical information including OI type, height and weight. Results: Information was gathered on a total of 77 children (60 type I, 4 type III and 13 type IV). Health conditions reported at birth included breech presentation (24%), prematurity (27%), fracture (18%), bone deformity (18%) and respiratory problems (22%). Approximately 31% (n = 24) received NICU care. There was a significant association between younger maternal age, preterm delivery and NICU admission. Conclusion: Our findings suggest that newborns with OI appear to be at high risk of skeletal disorders, preterm delivery and breech presentation. Younger maternal age and preterm delivery seem to be strong predictors of the need for NICU care. Our data suggest that pregnant women with OI younger than 20 years of age may benefit from added clinical supervision in anticipation of adverse effects on their child.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
DOIs
StateAccepted/In press - Mar 3 2016

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Osteogenesis Imperfecta
Neonatal Intensive Care Units
Cross-Sectional Studies
Newborn Infant
Health
Breech Presentation
Maternal Age
Parturition
Bone Fractures
Pregnant Women
Weights and Measures
Pregnancy

Keywords

  • Fracture
  • intensive care
  • neonatal outcomes
  • osteogenesis imperfecta
  • preterm delivery

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Health outcomes of neonates with osteogenesis imperfecta : a cross-sectional study. / Yimgang, Doris P.; Brizola, Evelise; Shapiro, Jay.

In: Journal of Maternal-Fetal and Neonatal Medicine, 03.03.2016, p. 1-5.

Research output: Contribution to journalArticle

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