TY - JOUR
T1 - Health outcomes of neonates with osteogenesis imperfecta
T2 - a cross-sectional study
AU - Yimgang, Doris P.
AU - Brizola, Evelise
AU - Shapiro, Jay R.
N1 - Publisher Copyright:
© 2016 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Objective: To assess at-birth health outcomes of neonates with osteogenesis imperfecta (OI). Study design: A total of 53 women who self-reported having had at least one child with OI completed the survey. We evaluated pregnancy length, neonatal intensive care unit (NICU) usage, at-birth complications, and the child’s clinical information including OI type, height and weight. Results: Information was gathered on a total of 77 children (60 type I, 4 type III and 13 type IV). Health conditions reported at birth included breech presentation (24%), prematurity (27%), fracture (18%), bone deformity (18%) and respiratory problems (22%). Approximately 31% (n = 24) received NICU care. There was a significant association between younger maternal age, preterm delivery and NICU admission. Conclusion: Our findings suggest that newborns with OI appear to be at high risk of skeletal disorders, preterm delivery and breech presentation. Younger maternal age and preterm delivery seem to be strong predictors of the need for NICU care. Our data suggest that pregnant women with OI younger than 20 years of age may benefit from added clinical supervision in anticipation of adverse effects on their child.
AB - Objective: To assess at-birth health outcomes of neonates with osteogenesis imperfecta (OI). Study design: A total of 53 women who self-reported having had at least one child with OI completed the survey. We evaluated pregnancy length, neonatal intensive care unit (NICU) usage, at-birth complications, and the child’s clinical information including OI type, height and weight. Results: Information was gathered on a total of 77 children (60 type I, 4 type III and 13 type IV). Health conditions reported at birth included breech presentation (24%), prematurity (27%), fracture (18%), bone deformity (18%) and respiratory problems (22%). Approximately 31% (n = 24) received NICU care. There was a significant association between younger maternal age, preterm delivery and NICU admission. Conclusion: Our findings suggest that newborns with OI appear to be at high risk of skeletal disorders, preterm delivery and breech presentation. Younger maternal age and preterm delivery seem to be strong predictors of the need for NICU care. Our data suggest that pregnant women with OI younger than 20 years of age may benefit from added clinical supervision in anticipation of adverse effects on their child.
KW - Fracture
KW - intensive care
KW - neonatal outcomes
KW - osteogenesis imperfecta
KW - preterm delivery
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U2 - 10.3109/14767058.2016.1151870
DO - 10.3109/14767058.2016.1151870
M3 - Article
C2 - 26857929
AN - SCOPUS:84961205603
SN - 1476-7058
VL - 29
SP - 3889
EP - 3893
JO - Journal of Maternal-Fetal and Neonatal Medicine
JF - Journal of Maternal-Fetal and Neonatal Medicine
IS - 23
ER -