Health and function of participants in the Long Life family study: A comparison with other cohorts

Anne B. Newman, Nancy W. Glynn, Christopher A. Taylor, Paola Sebastiani, Thomas T. Perls, Richard Mayeux, Kaare Christensen, Joseph M. Zmuda, Sandra Barral, Joseph H. Lee, Eleanor M. Simonsick, Jeremy D. Walston, Anatoli I. Yashin, Evan Hadley

Research output: Contribution to journalArticle

Abstract

Individuals from families recruited for the Long Life Family Study (LLFS) (n= 4559) were examined and compared to individuals from other cohorts to determine whether the recruitment targeting longevity resulted in a cohort of individuals with better health and function. Other cohorts with similar data included the Cardiovascular Health Study, the Framingham Heart Study, and the New England Centenarian Study. Diabetes, chronic pulmonary disease and peripheral artery disease tended to be less common in LLFS probands and offspring compared to similar aged persons in the other cohorts. Pulse pressure and triglycerides were lower, high density lipids were higher, and a perceptual speed task and gait speed were better in LLFS. Age-specific comparisons showed differences that would be consistent with a higher peak, later onset of decline or slower rate of change across age in LLFS participants. These findings suggest several priority phenotypes for inclusion in future genetic analysis to identify loci contributing to exceptional survival.

Original languageEnglish (US)
Pages (from-to)63-76
Number of pages14
JournalAging
Volume3
Issue number1
DOIs
StatePublished - Jan 2011

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Keywords

  • Aging phenotypes
  • Exceptional survival
  • Family studies
  • Genetics
  • Genome wide association study
  • Healthy aging
  • Longevity
  • Multicenter studies

ASJC Scopus subject areas

  • Aging
  • Cell Biology

Cite this

Newman, A. B., Glynn, N. W., Taylor, C. A., Sebastiani, P., Perls, T. T., Mayeux, R., Christensen, K., Zmuda, J. M., Barral, S., Lee, J. H., Simonsick, E. M., Walston, J. D., Yashin, A. I., & Hadley, E. (2011). Health and function of participants in the Long Life family study: A comparison with other cohorts. Aging, 3(1), 63-76. https://doi.org/10.18632/aging.100242