TY - JOUR
T1 - Head position during sleep
T2 - Potential implications for patients with neurodegenerative disease
AU - Levendowski, Daniel J.
AU - Gamaldo, Charlene
AU - St Louis, Erik K.
AU - Ferini-Strambi, Luigi
AU - Hamilton, Joanne M.
AU - Salat, David
AU - Westbrook, Philip R.
AU - Berka, Chris
N1 - Funding Information:
The authors acknowledge Greg Rupp, Stephanie Smith, and Kefron McCaw for their assistance with data acquisition, Amir Meghdadi and Marija Ste-vanovic Karik with data analysis support, and David P. Salmon and Doug Galasko for their expertise in recruitment of San Diego participants with AD and MCI. Brendan P. Lucey, David M. Holtzman, John C. Morris and their staff at the Department of Neurology, Washington University School of Medicine, St. Louis, MO acquired recordings from elderly subjects included as healthy controls, work supported by the NIH (P01-AG003991; 50-AG005681). Mr. Levendowski, Ms. Berka, and Dr. Westbrook were supported by the National Institute of Aging (NIA)-National Institute of Health (NIH) (R44AG050326; R44AG054256) with Chris Berka serving as the INSPECDS principal investigator. Dr. St. Louis received research support from the National Center for Research Resources and the National Center for Advancing Translational Sciences, NIH, through Grant Number 1 UL1 RR024150-01, and the Mayo Clinic Alzheimer’s Disease Research Center Grant Award from the NIA (P50 AG016574). Dr. Hamilton and her staff were supported by the INSPECDS grants as well as NIA grant P50-AG005131. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
Publisher Copyright:
© 2019 IOS Press and the authors. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Background: The characterization of sleep in those with neurodegenerative disease (NDD) is essential in understanding the potential neurobiological mechanisms that underlie the connection between sleep disruption and NDD manifestations and progression. Objective: Explore the inter-relationships between NDD and age, sex, diagnosis of obstructive sleep apnea, snoring, and duration of sleep time with the head in the supine and non-supine positions. Methods: A case-control design was used to evaluate differences in sleep position obtained from multi-night, in-home Sleep Profiler recordings in 45 patients with diagnosed NDD (24 with mild cognitive impairment, 15 with Alzheimer's disease, and 6 with Lewy Body, Parkinson's, or other dementias) and 120 age-sex matched controls with normal cognition (NC). Results: The frequency of supine sleep 2 h/night was significantly greater in the NDD than in the NC group (p < 0.001, odds ratio = 3.7), and remained significant after controlling for age, sex, snoring, and obstructive sleep apnea diagnosis (p = 0.01). There were no group differences in nocturnal mobility i.e., number of head position changes/h. Conclusion: This study demonstrates the utility of in-home measurements of sleep in defining the association of supine sleep position with neurodegenerative disorders. Our findings warrant further investigation, particularly in light of the recent evidence suggesting that sleep may an active role in the brain's ability to clear CNS neurotoxins and metabolites.
AB - Background: The characterization of sleep in those with neurodegenerative disease (NDD) is essential in understanding the potential neurobiological mechanisms that underlie the connection between sleep disruption and NDD manifestations and progression. Objective: Explore the inter-relationships between NDD and age, sex, diagnosis of obstructive sleep apnea, snoring, and duration of sleep time with the head in the supine and non-supine positions. Methods: A case-control design was used to evaluate differences in sleep position obtained from multi-night, in-home Sleep Profiler recordings in 45 patients with diagnosed NDD (24 with mild cognitive impairment, 15 with Alzheimer's disease, and 6 with Lewy Body, Parkinson's, or other dementias) and 120 age-sex matched controls with normal cognition (NC). Results: The frequency of supine sleep 2 h/night was significantly greater in the NDD than in the NC group (p < 0.001, odds ratio = 3.7), and remained significant after controlling for age, sex, snoring, and obstructive sleep apnea diagnosis (p = 0.01). There were no group differences in nocturnal mobility i.e., number of head position changes/h. Conclusion: This study demonstrates the utility of in-home measurements of sleep in defining the association of supine sleep position with neurodegenerative disorders. Our findings warrant further investigation, particularly in light of the recent evidence suggesting that sleep may an active role in the brain's ability to clear CNS neurotoxins and metabolites.
KW - Head position
KW - neurodegeneration
KW - obstructive sleep apnea
KW - sleep
KW - supine
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U2 - 10.3233/JAD-180697
DO - 10.3233/JAD-180697
M3 - Article
C2 - 30614805
AN - SCOPUS:85060576983
SN - 1387-2877
VL - 67
SP - 631
EP - 638
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 2
ER -