Head injury serum markers for assessing response to trauma: Design of the HeadSMART study

Matthew E. Peters; Vani Rao; Kathleen T. Bechtold; Durga Roy; Haris I. Sair; Jeannie Marie Leoutsakos; Ramon Diaz-Arrastia; Robert D. Stevens; D. Scott Batty; Hayley Falk; Christopher Fernandez; Uju Ofoche; Alexandra Vassila; Anna J. Hall; Braden Anderson; Edward Bessman; Constantine G. Lyketsos; Allen D. Everett; Jennifer Van Eyk; Frederick K. Korley

doi:10.1080/02699052.2016.1231344

Head injury serum markers for assessing response to trauma: Design of the HeadSMART study

Matthew E. Peters, Vani Rao, Kathleen T. Bechtold, Durga Roy, Haris I. Sair, Jeannie Marie Leoutsakos, Ramon Diaz-Arrastia, Robert D. Stevens, D. Scott Batty, Hayley Falk, Christopher Fernandez, Uju Ofoche, Alexandra Vassila, Anna J. Hall, Braden Anderson, Edward Bessman, Constantine G. Lyketsos, Allen D. Everett, Jennifer Van Eyk, Frederick K. Korley

School of Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Background: Accurate diagnosis and risk stratification of traumatic brain injury (TBI) at time of presentation remains a clinical challenge. The Head Injury Serum Markers for Assessing Response to Trauma study (HeadSMART) aims to examine blood-based biomarkers for diagnosing and determining prognosis in TBI. Methods: HeadSMART is a 6-month prospective cohort study comparing emergency department patients evaluated for TBI (exposure group) to (1) emergency department patients evaluated for traumatic injury without head trauma and (2) healthy persons. Study methods and characteristics of the first 300 exposure participants are discussed. Results: Of the first 300 participants in the exposure arm, 70% met the American Congress of Rehabilitation Medicine criteria for TBI, with the majority (80.1%) classified as mild TBI. The majority of subjects in the exposure arm had Glasgow Coma Scale scores of 13–15 (98.0%), normal head computed tomography (81.3%) and no prior history of concussion (71.7%). Conclusion: With systematic phenotyping, HeadSMART will facilitate diagnosis and risk-stratification of the heterogeneous group of individuals currently diagnosed with TBI.

Original language	English (US)
Pages (from-to)	370-378
Number of pages	9
Journal	Brain Injury
Volume	31
Issue number	3
DOIs	https://doi.org/10.1080/02699052.2016.1231344
State	Published - Feb 23 2017

Keywords

TBI
Traumatic brain injury
biomarkers
blunt head trauma

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Developmental and Educational Psychology
Clinical Neurology

Access to Document

10.1080/02699052.2016.1231344

Cite this

Peters, M. E., Rao, V., Bechtold, K. T., Roy, D., Sair, H. I., Leoutsakos, J. M., Diaz-Arrastia, R., Stevens, R. D., Batty, D. S., Falk, H., Fernandez, C., Ofoche, U., Vassila, A., Hall, A. J., Anderson, B., Bessman, E., Lyketsos, C. G., Everett, A. D., Van Eyk, J., & Korley, F. K. (2017). Head injury serum markers for assessing response to trauma: Design of the HeadSMART study. Brain Injury, 31(3), 370-378. https://doi.org/10.1080/02699052.2016.1231344

Peters, ME, Rao, V, Bechtold, KT, Roy, D , Sair, HI , Leoutsakos, JM, Diaz-Arrastia, R, Stevens, RD, Batty, DS, Falk, H, Fernandez, C, Ofoche, U, Vassila, A, Hall, AJ, Anderson, B, Bessman, E , Lyketsos, CG , Everett, AD, Van Eyk, J & Korley, FK 2017, 'Head injury serum markers for assessing response to trauma: Design of the HeadSMART study', Brain Injury, vol. 31, no. 3, pp. 370-378. https://doi.org/10.1080/02699052.2016.1231344

@article{3120356f7eed4085835aee56f37eed59,

title = "Head injury serum markers for assessing response to trauma: Design of the HeadSMART study",

abstract = "Background: Accurate diagnosis and risk stratification of traumatic brain injury (TBI) at time of presentation remains a clinical challenge. The Head Injury Serum Markers for Assessing Response to Trauma study (HeadSMART) aims to examine blood-based biomarkers for diagnosing and determining prognosis in TBI. Methods: HeadSMART is a 6-month prospective cohort study comparing emergency department patients evaluated for TBI (exposure group) to (1) emergency department patients evaluated for traumatic injury without head trauma and (2) healthy persons. Study methods and characteristics of the first 300 exposure participants are discussed. Results: Of the first 300 participants in the exposure arm, 70% met the American Congress of Rehabilitation Medicine criteria for TBI, with the majority (80.1%) classified as mild TBI. The majority of subjects in the exposure arm had Glasgow Coma Scale scores of 13–15 (98.0%), normal head computed tomography (81.3%) and no prior history of concussion (71.7%). Conclusion: With systematic phenotyping, HeadSMART will facilitate diagnosis and risk-stratification of the heterogeneous group of individuals currently diagnosed with TBI.",

keywords = "TBI, Traumatic brain injury, biomarkers, blunt head trauma",

author = "Peters, {Matthew E.} and Vani Rao and Bechtold, {Kathleen T.} and Durga Roy and Sair, {Haris I.} and Leoutsakos, {Jeannie Marie} and Ramon Diaz-Arrastia and Stevens, {Robert D.} and Batty, {D. Scott} and Hayley Falk and Christopher Fernandez and Uju Ofoche and Alexandra Vassila and Hall, {Anna J.} and Braden Anderson and Edward Bessman and Lyketsos, {Constantine G.} and Everett, {Allen D.} and {Van Eyk}, Jennifer and Korley, {Frederick K.}",

note = "Publisher Copyright: {\textcopyright} 2017 Taylor & Francis Group, LLC.",

year = "2017",

month = feb,

day = "23",

doi = "10.1080/02699052.2016.1231344",

language = "English (US)",

volume = "31",

pages = "370--378",

journal = "Brain Injury",

issn = "0269-9052",

publisher = "Informa Healthcare",

number = "3",

}

TY - JOUR

T1 - Head injury serum markers for assessing response to trauma

T2 - Design of the HeadSMART study

AU - Peters, Matthew E.

AU - Rao, Vani

AU - Bechtold, Kathleen T.

AU - Roy, Durga

AU - Sair, Haris I.

AU - Leoutsakos, Jeannie Marie

AU - Diaz-Arrastia, Ramon

AU - Stevens, Robert D.

AU - Batty, D. Scott

AU - Falk, Hayley

AU - Fernandez, Christopher

AU - Ofoche, Uju

AU - Vassila, Alexandra

AU - Hall, Anna J.

AU - Anderson, Braden

AU - Bessman, Edward

AU - Lyketsos, Constantine G.

AU - Everett, Allen D.

AU - Van Eyk, Jennifer

AU - Korley, Frederick K.

PY - 2017/2/23

Y1 - 2017/2/23

N2 - Background: Accurate diagnosis and risk stratification of traumatic brain injury (TBI) at time of presentation remains a clinical challenge. The Head Injury Serum Markers for Assessing Response to Trauma study (HeadSMART) aims to examine blood-based biomarkers for diagnosing and determining prognosis in TBI. Methods: HeadSMART is a 6-month prospective cohort study comparing emergency department patients evaluated for TBI (exposure group) to (1) emergency department patients evaluated for traumatic injury without head trauma and (2) healthy persons. Study methods and characteristics of the first 300 exposure participants are discussed. Results: Of the first 300 participants in the exposure arm, 70% met the American Congress of Rehabilitation Medicine criteria for TBI, with the majority (80.1%) classified as mild TBI. The majority of subjects in the exposure arm had Glasgow Coma Scale scores of 13–15 (98.0%), normal head computed tomography (81.3%) and no prior history of concussion (71.7%). Conclusion: With systematic phenotyping, HeadSMART will facilitate diagnosis and risk-stratification of the heterogeneous group of individuals currently diagnosed with TBI.

AB - Background: Accurate diagnosis and risk stratification of traumatic brain injury (TBI) at time of presentation remains a clinical challenge. The Head Injury Serum Markers for Assessing Response to Trauma study (HeadSMART) aims to examine blood-based biomarkers for diagnosing and determining prognosis in TBI. Methods: HeadSMART is a 6-month prospective cohort study comparing emergency department patients evaluated for TBI (exposure group) to (1) emergency department patients evaluated for traumatic injury without head trauma and (2) healthy persons. Study methods and characteristics of the first 300 exposure participants are discussed. Results: Of the first 300 participants in the exposure arm, 70% met the American Congress of Rehabilitation Medicine criteria for TBI, with the majority (80.1%) classified as mild TBI. The majority of subjects in the exposure arm had Glasgow Coma Scale scores of 13–15 (98.0%), normal head computed tomography (81.3%) and no prior history of concussion (71.7%). Conclusion: With systematic phenotyping, HeadSMART will facilitate diagnosis and risk-stratification of the heterogeneous group of individuals currently diagnosed with TBI.

KW - TBI

KW - Traumatic brain injury

KW - biomarkers

KW - blunt head trauma

UR - http://www.scopus.com/inward/record.url?scp=85011290477&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85011290477&partnerID=8YFLogxK

U2 - 10.1080/02699052.2016.1231344

DO - 10.1080/02699052.2016.1231344

M3 - Article

C2 - 28140672

AN - SCOPUS:85011290477

SN - 0269-9052

VL - 31

SP - 370

EP - 378

JO - Brain Injury

JF - Brain Injury

IS - 3

ER -

Head injury serum markers for assessing response to trauma: Design of the HeadSMART study

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this