TY - JOUR
T1 - Head injury and 25-year risk of dementia
AU - Schneider, Andrea L.C.
AU - Selvin, Elizabeth
AU - Latour, Lawrence
AU - Turtzo, L. Christine
AU - Coresh, Josef
AU - Mosley, Thomas
AU - Ling, Geoffrey
AU - Gottesman, Rebecca F.
N1 - Funding Information:
information: The Atherosclerosis Risk in Communities (ARIC) Study is carried out as a collaborative study supported by National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) contracts (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700005I, and HHSN268201700004I). Neurocognitive data are collected through NIH grants 2U01-HL-096812, 2U01-HL-096814, 2U01-HL-096899, 2U01-HL-096902, and 2U01-HL-096917 (from the NHLBI, the National Institute of Neurological Disorders and Stroke [NINDS], the National Institute on Aging [NIA], and the National Institute on Deafness and Other Communication Disorders [NIDCD]) and with previous brain MRI examinations funded by NHLBI grant R01-HL-70825.The authors thank the staff and participants of the ARIC Study for their contributions.
Funding Information:
: The Atherosclerosis Risk in Communities (ARIC) Study is carried out as a collaborative study supported by National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) contracts (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700005I, and HHSN268201700004I). Neurocognitive data are collected through NIH grants 2U01‐HL‐096812, 2U01‐HL‐096814, 2U01‐HL‐096899, 2U01‐HL‐096902, and 2U01‐HL‐096917 (from the NHLBI, the National Institute of Neurological Disorders and Stroke [NINDS], the National Institute on Aging [NIA], and the National Institute on Deafness and Other Communication Disorders [NIDCD]) and with previous brain MRI examinations funded by NHLBI grant R01‐HL‐70825. Funding information
Publisher Copyright:
© 2021 the Alzheimer's Association
PY - 2021/9
Y1 - 2021/9
N2 - Introduction: Head injury is associated with significant morbidity and mortality. Long-term associations of head injury with dementia in community-based populations are less clear. Methods: Prospective cohort study of 14,376 participants (mean age 54 years at baseline, 56% female, 27% Black, 24% with head injury) enrolled in the Atherosclerosis Risk in Communities (ARIC) Study. Head injury was defined using self-report and International Classification of Diseases, Ninth/Tenth Revision (ICD-9/10) codes. Dementia was defined using cognitive assessments, informant interviews, and ICD-9/10 and death certificate codes. Results: Head injury was associated with risk of dementia (hazard ratio [HR] = 1.44, 95% confidence interval [CI] = 1.3-1.57), with evidence of dose-response (1 head injury: HR = 1.25, 95% CI = 1.13-1.39, 2+ head injuries: HR = 2.14, 95% CI = 1.86-2.46). There was evidence for stronger associations among female participants (HR = 1.69, 95% CI = 1.51-1.90) versus male participants (HR = 1.15, 95% CI = 1.00-1.32), P-for-interaction <.001, and among White participants (HR = 1.55, 95% CI = 1.40-1.72) versus Black participants (HR = 1.22, 95% CI = 1.02-1.45), P-for-interaction =.008. Discussion: In this community-based cohort with 25-year follow-up, head injury was associated with increased dementia risk in a dose-dependent manner, with stronger associations among female participants and White participants.
AB - Introduction: Head injury is associated with significant morbidity and mortality. Long-term associations of head injury with dementia in community-based populations are less clear. Methods: Prospective cohort study of 14,376 participants (mean age 54 years at baseline, 56% female, 27% Black, 24% with head injury) enrolled in the Atherosclerosis Risk in Communities (ARIC) Study. Head injury was defined using self-report and International Classification of Diseases, Ninth/Tenth Revision (ICD-9/10) codes. Dementia was defined using cognitive assessments, informant interviews, and ICD-9/10 and death certificate codes. Results: Head injury was associated with risk of dementia (hazard ratio [HR] = 1.44, 95% confidence interval [CI] = 1.3-1.57), with evidence of dose-response (1 head injury: HR = 1.25, 95% CI = 1.13-1.39, 2+ head injuries: HR = 2.14, 95% CI = 1.86-2.46). There was evidence for stronger associations among female participants (HR = 1.69, 95% CI = 1.51-1.90) versus male participants (HR = 1.15, 95% CI = 1.00-1.32), P-for-interaction <.001, and among White participants (HR = 1.55, 95% CI = 1.40-1.72) versus Black participants (HR = 1.22, 95% CI = 1.02-1.45), P-for-interaction =.008. Discussion: In this community-based cohort with 25-year follow-up, head injury was associated with increased dementia risk in a dose-dependent manner, with stronger associations among female participants and White participants.
KW - cohort study
KW - dementia
KW - head injury
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U2 - 10.1002/alz.12315
DO - 10.1002/alz.12315
M3 - Article
C2 - 33687142
AN - SCOPUS:85102182166
VL - 17
SP - 1432
EP - 1441
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
SN - 1552-5260
IS - 9
ER -