Head and neck squamous cell carcinoma: Ambiguous human papillomavirus status, elevated p16, and deleted retinoblastoma 1

Tim N. Beck, Chad H. Smith, Douglas B. Flieder, Thomas J. Galloway, John A. Ridge, Erica A. Golemis, Ranee Mehra

Research output: Contribution to journalArticle

Abstract

Background: Head and neck squamous cell carcinoma (HNSCC) is potentially curable, but treatment planning remains a challenge. Oncogenic human papillomavirus (HPV)-positive disease is often associated with a good prognosis compared with HPV-negative disease. However, some HPV-positive HNSCC recurs, often with distant metastases and significant treatment resistance. Methods and Results: We performed p16 immunohistochemistry (IHC), in situ hybridization (ISH) for high-risk HPV, and comprehensive genomic profiling on oropharyngeal HNSCC with basaloid features and particularly aggressive disease course, noting a rare genetic event: a deleting mutation (exons 5–17) of the tumor suppressor and dominant cell cycle regulator retinoblastoma 1 (RB1). Genomic and transcriptomic data available through FoundationOne and The Cancer Genome Atlas (TCGA) were reviewed for additional HNSCC cases with RB1 alterations. Conclusion: RB1 alterations may have important prognostic implications, particularly in the context of high p16 expression, in both HPV-positive and HPV-negative HNSCC.

Original languageEnglish (US)
Pages (from-to)E34-E39
JournalHead and Neck
Volume39
Issue number3
DOIs
StatePublished - Mar 1 2017

Keywords

  • The Cancer Genome Atlas (TCGA)
  • head and neck squamous cell carcinoma
  • human papillomavirus
  • p16
  • retinoblastoma 1 (RB1)

ASJC Scopus subject areas

  • Otorhinolaryngology

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    Beck, T. N., Smith, C. H., Flieder, D. B., Galloway, T. J., Ridge, J. A., Golemis, E. A., & Mehra, R. (2017). Head and neck squamous cell carcinoma: Ambiguous human papillomavirus status, elevated p16, and deleted retinoblastoma 1. Head and Neck, 39(3), E34-E39. https://doi.org/10.1002/hed.24604