TY - JOUR
T1 - Head and neck neoplasms
T2 - Magnetization transfer analysis
AU - Yousem, David M.
AU - Montone, Kathleen T.
AU - Sheppard, Lisa M.
AU - Rao, Vijay M.
AU - Weinstein, Gregory S.
AU - Hayden, Richard E.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1994/9
Y1 - 1994/9
N2 - PURPOSE: Magnetization transfer (MT) imaging enables analysis of the contribution of restricted motion protons in the macromolecular pool to magnetic resonance (MR) signal intensity. The authors undertook this study to determine whether MT ratios (MTRs) could be used to predict pathologic characteristics of head and neck neoplasms. MATERIALS AND METHODS: Fifty- four patients with pathologically proved neoplasms (squamous cell carcinomas, n = 33; non-squamous cell carcinomas, n = 11; benign masses, n = 10) underwent MT imaging. MTRs were correlated with pathologic findings. RESULTS: No statistically significant correlations were noted between MTRs and degree of differentiation, keratinization, cells per high-power field, and rate of mitosis. Statistically significant differences were found between MTRs of malignancies and muscle (P < .01), cerebrospinal fluid (P < .001), fat (P < .001), and benign neoplasms (P < .001). MTRs of muscle were higher than those of benign, squamous cell, and non-squamous cell neoplasms. CONCLUSION: MT imaging shows promise in differentiation of benign from malignant head and neck neoplasms. No statistically significant differences in MTRs were noted among malignancies.
AB - PURPOSE: Magnetization transfer (MT) imaging enables analysis of the contribution of restricted motion protons in the macromolecular pool to magnetic resonance (MR) signal intensity. The authors undertook this study to determine whether MT ratios (MTRs) could be used to predict pathologic characteristics of head and neck neoplasms. MATERIALS AND METHODS: Fifty- four patients with pathologically proved neoplasms (squamous cell carcinomas, n = 33; non-squamous cell carcinomas, n = 11; benign masses, n = 10) underwent MT imaging. MTRs were correlated with pathologic findings. RESULTS: No statistically significant correlations were noted between MTRs and degree of differentiation, keratinization, cells per high-power field, and rate of mitosis. Statistically significant differences were found between MTRs of malignancies and muscle (P < .01), cerebrospinal fluid (P < .001), fat (P < .001), and benign neoplasms (P < .001). MTRs of muscle were higher than those of benign, squamous cell, and non-squamous cell neoplasms. CONCLUSION: MT imaging shows promise in differentiation of benign from malignant head and neck neoplasms. No statistically significant differences in MTRs were noted among malignancies.
KW - Head and neck neoplasms, MR
KW - Head and neck neoplasms, diagnosis
KW - Magnetic resonance (MR), magnetization transfer contrast
UR - http://www.scopus.com/inward/record.url?scp=0028030991&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028030991&partnerID=8YFLogxK
U2 - 10.1148/radiology.192.3.8058937
DO - 10.1148/radiology.192.3.8058937
M3 - Article
C2 - 8058937
AN - SCOPUS:0028030991
SN - 0033-8419
VL - 192
SP - 703
EP - 707
JO - RADIOLOGY
JF - RADIOLOGY
IS - 3
ER -