TY - JOUR
T1 - Head and Neck Cancer
T2 - Relationship of the Prechemotherapy Serum Alkaline Phosphatase Levels to Response Rate of Induction Chemotherapy
AU - Coker, Donald D.
AU - Morris, Don
AU - Elias, E. George
AU - Didolkar, Mukund S.
AU - Zentai, Theresa A.
PY - 1982/1
Y1 - 1982/1
N2 - Fifty-one patients with stage III or IV squamous cell carcinoma of the head and neck who received induction chemotherapy with cisplatin and bleomycin sulfate with and without high-dose methotrexate were studied. The relationship of the prechemotherapy levels of serum alkaline phosphatase, lactic dehydrogenase, SGOT, SGPT, BUN, creatinine, calcium, total protein, albumin, hemoglobin, uric acid, and bilirubin and the WBC and platelet counts was correlated with the response rate. The overall response rate was 65%. No notable relationship between any of the laboratory values and the response rate was found. In contrast to an earlier report, patients with a low alkaline phosphatase level responded as well as patients with an elevated serum alkaline phosphatase level.
AB - Fifty-one patients with stage III or IV squamous cell carcinoma of the head and neck who received induction chemotherapy with cisplatin and bleomycin sulfate with and without high-dose methotrexate were studied. The relationship of the prechemotherapy levels of serum alkaline phosphatase, lactic dehydrogenase, SGOT, SGPT, BUN, creatinine, calcium, total protein, albumin, hemoglobin, uric acid, and bilirubin and the WBC and platelet counts was correlated with the response rate. The overall response rate was 65%. No notable relationship between any of the laboratory values and the response rate was found. In contrast to an earlier report, patients with a low alkaline phosphatase level responded as well as patients with an elevated serum alkaline phosphatase level.
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U2 - 10.1001/archotol.1982.00790490030007
DO - 10.1001/archotol.1982.00790490030007
M3 - Article
C2 - 6172102
AN - SCOPUS:0020084327
SN - 0003-9977
VL - 108
SP - 28
EP - 29
JO - Archives of Otolaryngology
JF - Archives of Otolaryngology
IS - 1
ER -