HDL-cholesterol and the incidence of lung cancer in the Atherosclerosis Risk in Communities (ARIC) study

Anna M. Kucharska-Newton, Wayne D. Rosamond, Jane C. Schroeder, Ann Marie McNeill, Josef Coresh, Aaron R. Folsom

Research output: Contribution to journalArticle

Abstract

This study examined prospectively the association of baseline plasma HDL-cholesterol levels with incidence of lung cancer in 14,547 members of the Atherosclerosis Risk in Communities (ARIC) cohort. There were 259 cases of incident lung cancer identified during follow-up from 1987 through 2000. Results of this study indicated a relatively weak inverse association of HDL-cholesterol with lung cancer that was dependent on smoking status. The hazard ratio of lung cancer incidence in relation to low HDL-cholesterol, adjusted for race, gender, exercise, alcohol consumption, body mass index, triglycerides, age, and cigarette pack-years of smoking, was 1.45 (95% confidence interval 1.10, 1.92). This association was observed among former smokers (hazard ratio: 1.77, 95% confidence interval 1.05, 2.97), but not current smokers. The number of cases among never smokers in this study was too small (n = 13) for meaningful interpretation of effect estimates. Excluding cases occurring within 5 years of baseline did not appreciably change the point estimates, suggesting lack of reverse causality. The modest association of low plasma HDL-cholesterol with greater incident lung cancer observed in this study is in agreement with existing case-control studies.

Original languageEnglish (US)
Pages (from-to)292-300
Number of pages9
JournalLung Cancer
Volume61
Issue number3
DOIs
StatePublished - Sep 2008

Fingerprint

HDL Cholesterol
Lung Neoplasms
Atherosclerosis
Incidence
Smoking
Confidence Intervals
Tobacco Products
Alcohol Drinking
Causality
Case-Control Studies
Triglycerides
Body Mass Index
Exercise

Keywords

  • Cohort studies
  • HDL-cholesterol
  • Lipoproteins
  • Lung neoplasms

ASJC Scopus subject areas

  • Oncology

Cite this

Kucharska-Newton, A. M., Rosamond, W. D., Schroeder, J. C., McNeill, A. M., Coresh, J., & Folsom, A. R. (2008). HDL-cholesterol and the incidence of lung cancer in the Atherosclerosis Risk in Communities (ARIC) study. Lung Cancer, 61(3), 292-300. https://doi.org/10.1016/j.lungcan.2008.01.015

HDL-cholesterol and the incidence of lung cancer in the Atherosclerosis Risk in Communities (ARIC) study. / Kucharska-Newton, Anna M.; Rosamond, Wayne D.; Schroeder, Jane C.; McNeill, Ann Marie; Coresh, Josef; Folsom, Aaron R.

In: Lung Cancer, Vol. 61, No. 3, 09.2008, p. 292-300.

Research output: Contribution to journalArticle

Kucharska-Newton, AM, Rosamond, WD, Schroeder, JC, McNeill, AM, Coresh, J & Folsom, AR 2008, 'HDL-cholesterol and the incidence of lung cancer in the Atherosclerosis Risk in Communities (ARIC) study', Lung Cancer, vol. 61, no. 3, pp. 292-300. https://doi.org/10.1016/j.lungcan.2008.01.015
Kucharska-Newton, Anna M. ; Rosamond, Wayne D. ; Schroeder, Jane C. ; McNeill, Ann Marie ; Coresh, Josef ; Folsom, Aaron R. / HDL-cholesterol and the incidence of lung cancer in the Atherosclerosis Risk in Communities (ARIC) study. In: Lung Cancer. 2008 ; Vol. 61, No. 3. pp. 292-300.
@article{c2c40fe6dd194036b35783cea87e434f,
title = "HDL-cholesterol and the incidence of lung cancer in the Atherosclerosis Risk in Communities (ARIC) study",
abstract = "This study examined prospectively the association of baseline plasma HDL-cholesterol levels with incidence of lung cancer in 14,547 members of the Atherosclerosis Risk in Communities (ARIC) cohort. There were 259 cases of incident lung cancer identified during follow-up from 1987 through 2000. Results of this study indicated a relatively weak inverse association of HDL-cholesterol with lung cancer that was dependent on smoking status. The hazard ratio of lung cancer incidence in relation to low HDL-cholesterol, adjusted for race, gender, exercise, alcohol consumption, body mass index, triglycerides, age, and cigarette pack-years of smoking, was 1.45 (95{\%} confidence interval 1.10, 1.92). This association was observed among former smokers (hazard ratio: 1.77, 95{\%} confidence interval 1.05, 2.97), but not current smokers. The number of cases among never smokers in this study was too small (n = 13) for meaningful interpretation of effect estimates. Excluding cases occurring within 5 years of baseline did not appreciably change the point estimates, suggesting lack of reverse causality. The modest association of low plasma HDL-cholesterol with greater incident lung cancer observed in this study is in agreement with existing case-control studies.",
keywords = "Cohort studies, HDL-cholesterol, Lipoproteins, Lung neoplasms",
author = "Kucharska-Newton, {Anna M.} and Rosamond, {Wayne D.} and Schroeder, {Jane C.} and McNeill, {Ann Marie} and Josef Coresh and Folsom, {Aaron R.}",
year = "2008",
month = "9",
doi = "10.1016/j.lungcan.2008.01.015",
language = "English (US)",
volume = "61",
pages = "292--300",
journal = "Lung Cancer",
issn = "0169-5002",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - HDL-cholesterol and the incidence of lung cancer in the Atherosclerosis Risk in Communities (ARIC) study

AU - Kucharska-Newton, Anna M.

AU - Rosamond, Wayne D.

AU - Schroeder, Jane C.

AU - McNeill, Ann Marie

AU - Coresh, Josef

AU - Folsom, Aaron R.

PY - 2008/9

Y1 - 2008/9

N2 - This study examined prospectively the association of baseline plasma HDL-cholesterol levels with incidence of lung cancer in 14,547 members of the Atherosclerosis Risk in Communities (ARIC) cohort. There were 259 cases of incident lung cancer identified during follow-up from 1987 through 2000. Results of this study indicated a relatively weak inverse association of HDL-cholesterol with lung cancer that was dependent on smoking status. The hazard ratio of lung cancer incidence in relation to low HDL-cholesterol, adjusted for race, gender, exercise, alcohol consumption, body mass index, triglycerides, age, and cigarette pack-years of smoking, was 1.45 (95% confidence interval 1.10, 1.92). This association was observed among former smokers (hazard ratio: 1.77, 95% confidence interval 1.05, 2.97), but not current smokers. The number of cases among never smokers in this study was too small (n = 13) for meaningful interpretation of effect estimates. Excluding cases occurring within 5 years of baseline did not appreciably change the point estimates, suggesting lack of reverse causality. The modest association of low plasma HDL-cholesterol with greater incident lung cancer observed in this study is in agreement with existing case-control studies.

AB - This study examined prospectively the association of baseline plasma HDL-cholesterol levels with incidence of lung cancer in 14,547 members of the Atherosclerosis Risk in Communities (ARIC) cohort. There were 259 cases of incident lung cancer identified during follow-up from 1987 through 2000. Results of this study indicated a relatively weak inverse association of HDL-cholesterol with lung cancer that was dependent on smoking status. The hazard ratio of lung cancer incidence in relation to low HDL-cholesterol, adjusted for race, gender, exercise, alcohol consumption, body mass index, triglycerides, age, and cigarette pack-years of smoking, was 1.45 (95% confidence interval 1.10, 1.92). This association was observed among former smokers (hazard ratio: 1.77, 95% confidence interval 1.05, 2.97), but not current smokers. The number of cases among never smokers in this study was too small (n = 13) for meaningful interpretation of effect estimates. Excluding cases occurring within 5 years of baseline did not appreciably change the point estimates, suggesting lack of reverse causality. The modest association of low plasma HDL-cholesterol with greater incident lung cancer observed in this study is in agreement with existing case-control studies.

KW - Cohort studies

KW - HDL-cholesterol

KW - Lipoproteins

KW - Lung neoplasms

UR - http://www.scopus.com/inward/record.url?scp=50849121989&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=50849121989&partnerID=8YFLogxK

U2 - 10.1016/j.lungcan.2008.01.015

DO - 10.1016/j.lungcan.2008.01.015

M3 - Article

C2 - 18342390

AN - SCOPUS:50849121989

VL - 61

SP - 292

EP - 300

JO - Lung Cancer

JF - Lung Cancer

SN - 0169-5002

IS - 3

ER -