HDAC6 at the Intersection of Neuroprotection and Neurodegeneration

Constantin d'Ydewalle; Elke Bogaert; Ludo Van Den Bosch

doi:10.1111/j.1600-0854.2012.01347.x

HDAC6 at the Intersection of Neuroprotection and Neurodegeneration

Constantin d'Ydewalle, Elke Bogaert, Ludo Van Den Bosch

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

Histone deacetylase 6 (HDAC6) catalyzes multiple reactions. We summarize the current knowledge on HDAC6, its targets and functions. Among others, HDAC6 recognizes damaged proteins and assures that these proteins are destroyed by autophagy. On the other hand, HDAC6 also modifies the tracks used by the clearance mechanism so that axonal transport becomes less efficient. We hypothesize that a disturbance in the equilibrium between the different functions of HDAC6 could play an important role in neurodegeneration.

Original language	English (US)
Pages (from-to)	771-779
Number of pages	9
Journal	Traffic
Volume	13
Issue number	6
DOIs	https://doi.org/10.1111/j.1600-0854.2012.01347.x
State	Published - Jun 2012
Externally published	Yes

Keywords

Autophagy
Axonal transport
Deacetylation
HDAC6
Microtubules
Neurodegeneration
Post-translational modifications

ASJC Scopus subject areas

Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1111/j.1600-0854.2012.01347.x

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abstract = "Histone deacetylase 6 (HDAC6) catalyzes multiple reactions. We summarize the current knowledge on HDAC6, its targets and functions. Among others, HDAC6 recognizes damaged proteins and assures that these proteins are destroyed by autophagy. On the other hand, HDAC6 also modifies the tracks used by the clearance mechanism so that axonal transport becomes less efficient. We hypothesize that a disturbance in the equilibrium between the different functions of HDAC6 could play an important role in neurodegeneration.",

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author = "Constantin d'Ydewalle and Elke Bogaert and {Van Den Bosch}, Ludo",

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AU - Bogaert, Elke

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N2 - Histone deacetylase 6 (HDAC6) catalyzes multiple reactions. We summarize the current knowledge on HDAC6, its targets and functions. Among others, HDAC6 recognizes damaged proteins and assures that these proteins are destroyed by autophagy. On the other hand, HDAC6 also modifies the tracks used by the clearance mechanism so that axonal transport becomes less efficient. We hypothesize that a disturbance in the equilibrium between the different functions of HDAC6 could play an important role in neurodegeneration.

AB - Histone deacetylase 6 (HDAC6) catalyzes multiple reactions. We summarize the current knowledge on HDAC6, its targets and functions. Among others, HDAC6 recognizes damaged proteins and assures that these proteins are destroyed by autophagy. On the other hand, HDAC6 also modifies the tracks used by the clearance mechanism so that axonal transport becomes less efficient. We hypothesize that a disturbance in the equilibrium between the different functions of HDAC6 could play an important role in neurodegeneration.

KW - Autophagy

KW - Axonal transport

KW - Deacetylation

KW - HDAC6

KW - Microtubules

KW - Neurodegeneration

KW - Post-translational modifications

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HDAC6 at the Intersection of Neuroprotection and Neurodegeneration

Abstract

Keywords

ASJC Scopus subject areas

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