HDAC6 at the Intersection of Neuroprotection and Neurodegeneration

Constantin d'Ydewalle, Elke Bogaert, Ludo Van Den Bosch

Research output: Contribution to journalReview articlepeer-review

Abstract

Histone deacetylase 6 (HDAC6) catalyzes multiple reactions. We summarize the current knowledge on HDAC6, its targets and functions. Among others, HDAC6 recognizes damaged proteins and assures that these proteins are destroyed by autophagy. On the other hand, HDAC6 also modifies the tracks used by the clearance mechanism so that axonal transport becomes less efficient. We hypothesize that a disturbance in the equilibrium between the different functions of HDAC6 could play an important role in neurodegeneration.

Original languageEnglish (US)
Pages (from-to)771-779
Number of pages9
JournalTraffic
Volume13
Issue number6
DOIs
StatePublished - Jun 2012

Keywords

  • Autophagy
  • Axonal transport
  • Deacetylation
  • HDAC6
  • Microtubules
  • Neurodegeneration
  • Post-translational modifications

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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