HCV RNA in patients with chronic hepatitis C treated with interferon-α

T. J. Liang, V. Rustgi, E. Galun, H. E. Blum

Research output: Contribution to journalArticle

Abstract

In order to assess the efficacy of interferon-α on hepatitis C viral RNA in patients with chronic hepatitis C, we analyzed the levels of HCV RNA in sera and liver tissues of 16 patients pre- and posttreatment using a semiquantitative polymerase chain reaction method. Fifteen of 16 patients were positive for anti-HCV antibodies by four-antigen recombinant immunoblot assay (4-RIBA). Only two patients demonstrated normalization of ALT in response to interferon; three patients showed a partial response. Only one patient from the partial responder group displayed a significant reduction of HCV RNA level posttreatment. In the nonresponder group, several patients, although their ALTs remained elevated, demonstrated significant decreases in HCV RNA levels in either serum or liver in response to interferon. Our data suggest that interferon treatment of chronic hepatitis C may not be effective in eradicating HCV infection and a reduction in ALT is infrequently associated with a decrease in HCV RNA level in either serum or liver. Cessation of treatment is frequently associated with the recrudescence of HCV replication and disease.

Original languageEnglish (US)
Pages (from-to)69-75
Number of pages7
JournalJournal of Medical Virology
Volume40
Issue number1
StatePublished - 1993
Externally publishedYes

Fingerprint

Chronic Hepatitis C
Interferons
RNA
Liver
Serum
Withholding Treatment
Hepatitis C Antibodies
Viral RNA
Hepatitis C
Antigens
Recurrence
Polymerase Chain Reaction
Infection

Keywords

  • non-B hepatitis/RIBA
  • RT-PCR/non-A

ASJC Scopus subject areas

  • Virology

Cite this

Liang, T. J., Rustgi, V., Galun, E., & Blum, H. E. (1993). HCV RNA in patients with chronic hepatitis C treated with interferon-α. Journal of Medical Virology, 40(1), 69-75.

HCV RNA in patients with chronic hepatitis C treated with interferon-α. / Liang, T. J.; Rustgi, V.; Galun, E.; Blum, H. E.

In: Journal of Medical Virology, Vol. 40, No. 1, 1993, p. 69-75.

Research output: Contribution to journalArticle

Liang, TJ, Rustgi, V, Galun, E & Blum, HE 1993, 'HCV RNA in patients with chronic hepatitis C treated with interferon-α', Journal of Medical Virology, vol. 40, no. 1, pp. 69-75.
Liang, T. J. ; Rustgi, V. ; Galun, E. ; Blum, H. E. / HCV RNA in patients with chronic hepatitis C treated with interferon-α. In: Journal of Medical Virology. 1993 ; Vol. 40, No. 1. pp. 69-75.
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