Hb A1c in relation to intrauterine growth among male adolescents in southern Brazil

A. Nazmi; S. R. Huttly; C. G. Victora; R. C. Lima; P. R. Post; J. W L Elizalde; B. M C Gerson

doi:10.1038/sj.ejcn.1602535

Hb A1c in relation to intrauterine growth among male adolescents in southern Brazil

A. Nazmi, S. R. Huttly, C. G. Victora, R. C. Lima, P. R. Post, J. W L Elizalde, B. M C Gerson

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7 Scopus citations

Abstract

The fetal origins hypothesis states that nutritional deprivation in utero affects fetal development and contributes to the incidence of diseases associated with the metabolic syndrome in later life. This study investigated whether haemoglobin (Hb) A_1c, an indicator of blood glucose, varied among healthy male adolescents according to their fetal growth rate, in a middle-income setting. Participants were men aged 18 years, belonging to the 1982 Pelotas birth cohort. Complete data, including gestational age and Hb A_1c at age 18 years, were available for 197 individuals. There was an inverse association between mean Hb A_1c and birthweight for the gestational age, but not birthweight alone. The association remained significant after adjustment for family income and mother's education, as well as for body mass index at 18 years (P for trend=0.01 and 0.03, respectively).

Original language	English (US)
Pages (from-to)	434-437
Number of pages	4
Journal	European Journal of Clinical Nutrition
Volume	61
Issue number	3
DOIs	https://doi.org/10.1038/sj.ejcn.1602535
State	Published - Mar 2007
Externally published	Yes

ASJC Scopus subject areas

Medicine (miscellaneous)
Food Science

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title = "Hb A1c in relation to intrauterine growth among male adolescents in southern Brazil",

abstract = "The fetal origins hypothesis states that nutritional deprivation in utero affects fetal development and contributes to the incidence of diseases associated with the metabolic syndrome in later life. This study investigated whether haemoglobin (Hb) A1c, an indicator of blood glucose, varied among healthy male adolescents according to their fetal growth rate, in a middle-income setting. Participants were men aged 18 years, belonging to the 1982 Pelotas birth cohort. Complete data, including gestational age and Hb A1c at age 18 years, were available for 197 individuals. There was an inverse association between mean Hb A1c and birthweight for the gestational age, but not birthweight alone. The association remained significant after adjustment for family income and mother's education, as well as for body mass index at 18 years (P for trend=0.01 and 0.03, respectively).",

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T1 - Hb A1c in relation to intrauterine growth among male adolescents in southern Brazil

AU - Nazmi, A.

AU - Huttly, S. R.

AU - Victora, C. G.

AU - Lima, R. C.

AU - Post, P. R.

AU - Elizalde, J. W L

AU - Gerson, B. M C

PY - 2007/3

Y1 - 2007/3

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AB - The fetal origins hypothesis states that nutritional deprivation in utero affects fetal development and contributes to the incidence of diseases associated with the metabolic syndrome in later life. This study investigated whether haemoglobin (Hb) A1c, an indicator of blood glucose, varied among healthy male adolescents according to their fetal growth rate, in a middle-income setting. Participants were men aged 18 years, belonging to the 1982 Pelotas birth cohort. Complete data, including gestational age and Hb A1c at age 18 years, were available for 197 individuals. There was an inverse association between mean Hb A1c and birthweight for the gestational age, but not birthweight alone. The association remained significant after adjustment for family income and mother's education, as well as for body mass index at 18 years (P for trend=0.01 and 0.03, respectively).

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Hb A1c in relation to intrauterine growth among male adolescents in southern Brazil

Abstract

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