TY - JOUR
T1 - Harvard HIV and aging workshop
T2 - Perspectives and Priorities from Claude D. Pepper Centers and Centers for AIDS Research
AU - Montano, Monty
AU - Bhasin, Shalender
AU - D'Aquila, Richard T.
AU - Erlandson, Kristine M.
AU - Evans, William J.
AU - Funderburg, Nicholas T.
AU - Justice, Amy
AU - Ndhlovu, Lishomwa C.
AU - Ojikutu, Bisola
AU - Pahor, Marco
AU - Pahwa, Savita
AU - Ryan, Alice S.
AU - Schrack, Jennifer
AU - Schultz, Michael B.
AU - Sebastiani, Paola
AU - Sinclair, David A.
AU - Tripp, Julia
AU - Walker, Bruce
AU - Womack, Julie A.
AU - Yung, Raymond
AU - Reeves, R. Keith
N1 - Funding Information:
cART, combination antiretroviral therapy; CNS, central nervous system; NCI, National Cancer Institute; NHLBI, National Heart Lung and Blood Institute; NIA, National Institute on Aging; NIAAA, National Institute on Alcohol Abuse and Alcoholism; NIAMS, National Institute of Arthritis and Musculoskeletal and Skin Diseases; NIDA, National Institute on Drug Abuse; NIDCR, National Institute of Dental and Craniofacial Research; NIMH, National Institute of Mental Health; NINDS, National Institute of Neurological Disorders and Stroke.
Funding Information:
This work was supported by the following grants from the National Institutes of Health: M.M. was supported by the NIA (R21 AG055415), the NIAID (R01 AI08541), and the Boston Older Americans Independence Center (P30 AG031679). K.M.E. was supported by the NIA (K23 AG050260 and R01 AG054366). D.A.S. was supported by the Glenn Foundation for Medical Research and grants from the NIH (R37 AG028730, R01 AG019719, and R01 DK100263). R.K.R. was supported by the NIAID (R01 AI120828) and NIDCR (R01 DE026014). The Harvard University Center for AIDS Research (P30 AI060354) provided logistical and organizational support for workshop.
Funding Information:
interest included measures of physical function, cognitive function, body composition, patient-reported outcomes (PROs), falls, and estimates of cost effectiveness, and exercise as medicine.32–38 The fifth and final session focused on NIH support for HIV and aging research. The speaker Basil Eldadah described the view from the National Institute on Aging (NIA) and led a panel discussion [Geraldina Dom-inguez/National Cancer Institute (NCI), Gallya Gannot/ National Institute of Dental and Craniofacial Research (NIDCR), Leia Novak/ National Heart Lung and Blood Institute (NHLBI)] on initiatives and emerging opportunities (Table 1). The following sections in this review reflect a summary of major themes of discussion across the sections, as well as conversations emerging from the community panel discussion.
Publisher Copyright:
© Copyright 2019, Mary Ann Liebert, Inc.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - People aging with HIV (PAWH) infection experience greater impairments in physical and cognitive function, in addition to higher rates of peripheral comorbid conditions (e.g., renal failure, diabetes, bone fracture, hypertension, cardiovascular disease, polypharmacy, and multimorbidity). While multifactorial drivers, including HIV infection itself, antiretroviral therapy-related toxicities, disparities in care, and biobehavioral factors, likely contribute, there remains an overarching question as to what are the relevant age-related mechanisms and models that could inform interventions that promote health span and life span in PAWH This workshop was convened to hear from experts on the biology of aging and HIV researchers studying PAWH to focus on advancing investigations at the interface of HIV and Aging. In this study, we summarize the discussions from the Harvard Center for AIDS Research and Boston Claude D. Pepper cosponsored workshop on HIV and Aging, which took place in October 2018.
AB - People aging with HIV (PAWH) infection experience greater impairments in physical and cognitive function, in addition to higher rates of peripheral comorbid conditions (e.g., renal failure, diabetes, bone fracture, hypertension, cardiovascular disease, polypharmacy, and multimorbidity). While multifactorial drivers, including HIV infection itself, antiretroviral therapy-related toxicities, disparities in care, and biobehavioral factors, likely contribute, there remains an overarching question as to what are the relevant age-related mechanisms and models that could inform interventions that promote health span and life span in PAWH This workshop was convened to hear from experts on the biology of aging and HIV researchers studying PAWH to focus on advancing investigations at the interface of HIV and Aging. In this study, we summarize the discussions from the Harvard Center for AIDS Research and Boston Claude D. Pepper cosponsored workshop on HIV and Aging, which took place in October 2018.
KW - HIV
KW - aging
KW - frailty
KW - immune activation
UR - http://www.scopus.com/inward/record.url?scp=85075093442&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85075093442&partnerID=8YFLogxK
U2 - 10.1089/aid.2019.0130
DO - 10.1089/aid.2019.0130
M3 - Article
C2 - 31456412
AN - SCOPUS:85075093442
VL - 35
SP - 999
EP - 1012
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
SN - 0889-2229
IS - 11-12
ER -