Harnessing the biology of IL-7 for therapeutic application

Crystal L. MacKall, Terry J. Fry, Ronald E. Gress

Research output: Contribution to journalArticle

Abstract

Interleukin-7 (IL-7) is required for T cell development and for maintaining and restoring homeostasis of mature T cells. IL-7 is a limiting resource under normal conditions, but it accumulates during lymphopaenia, leading to increased T cell proliferation. The administration of recombinant human IL-7 to normal or lymphopenic mice, non-human primates and humans results in widespread T cell proliferation, increased T cell numbers, modulation of peripheral T cell subsets and increased T cell receptor repertoire diversity. These effects raise the prospect that IL-7 could mediate therapeutic benefits in several clinical settings. This Review summarizes the biology of IL-7 and the results of its clinical use that are available so far to provide a perspective on the opportunities for clinical application of this cytokine.

Original languageEnglish (US)
Pages (from-to)330-342
Number of pages13
JournalNature Reviews Immunology
Volume11
Issue number5
DOIs
StatePublished - May 2011
Externally publishedYes

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Interleukin-7
T-Lymphocytes
Cell Proliferation
Therapeutics
Lymphopenia
T-Lymphocyte Subsets
T-Cell Antigen Receptor
Primates
Homeostasis
Cell Count
Cytokines

ASJC Scopus subject areas

  • Immunology

Cite this

Harnessing the biology of IL-7 for therapeutic application. / MacKall, Crystal L.; Fry, Terry J.; Gress, Ronald E.

In: Nature Reviews Immunology, Vol. 11, No. 5, 05.2011, p. 330-342.

Research output: Contribution to journalArticle

MacKall, Crystal L. ; Fry, Terry J. ; Gress, Ronald E. / Harnessing the biology of IL-7 for therapeutic application. In: Nature Reviews Immunology. 2011 ; Vol. 11, No. 5. pp. 330-342.
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