Harnessing Endogenous Stem Cells for Central Nervous System Repair

D. Chichung Lie, Sophia A. Colamarino, Hongjun Song, Fred H. Gage

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter examines the potential of endogenous stem cells to contribute to functional repair of the human central nervous system (CNS). The observation that endogenous stem cells can be recruited to generate new neurons following lesion is highly exciting and reinforces ones efforts to develop strategies that aim at harnessing endogenous stem cells for repair of the adult CNS. The molecular mechanisms that control adult neurogenesis are poorly understood. There are multiple growth factors, hormones, and neurotransmitters implicated in the regulation of neurogenesis, based on their ability to influence proliferation, differentiation, and survival of neural stem cells in vitro and in vivo. Their potential to affect the behavior of neural stem cells in vivo, these factors and their receptors might represent candidate molecules and targets, respectively, for the recruitment of endogenous stem cells for CNS repair. Furthermore, new neurons and glial cells generated in some CNS regions following injury suggests a potential for self-repair in the adult CNS by cell replacement from endogenous stem cells.

Original languageEnglish (US)
Title of host publicationFrom NEUROSCIENCE To NEUROLOGY
PublisherElsevier Inc.
Pages387-403
Number of pages17
ISBN (Print)9780127389035
DOIs
StatePublished - 2005

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Stem Cells
Central Nervous System
Neural Stem Cells
Neurogenesis
Neurons
Adult Stem Cells
Aptitude
Neuroglia
Growth Hormone
Neurotransmitter Agents
Intercellular Signaling Peptides and Proteins
Wounds and Injuries

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)

Cite this

Chichung Lie, D., Colamarino, S. A., Song, H., & Gage, F. H. (2005). Harnessing Endogenous Stem Cells for Central Nervous System Repair. In From NEUROSCIENCE To NEUROLOGY (pp. 387-403). Elsevier Inc.. https://doi.org/10.1016/B978-012738903-5/50024-2

Harnessing Endogenous Stem Cells for Central Nervous System Repair. / Chichung Lie, D.; Colamarino, Sophia A.; Song, Hongjun; Gage, Fred H.

From NEUROSCIENCE To NEUROLOGY. Elsevier Inc., 2005. p. 387-403.

Research output: Chapter in Book/Report/Conference proceedingChapter

Chichung Lie, D, Colamarino, SA, Song, H & Gage, FH 2005, Harnessing Endogenous Stem Cells for Central Nervous System Repair. in From NEUROSCIENCE To NEUROLOGY. Elsevier Inc., pp. 387-403. https://doi.org/10.1016/B978-012738903-5/50024-2
Chichung Lie D, Colamarino SA, Song H, Gage FH. Harnessing Endogenous Stem Cells for Central Nervous System Repair. In From NEUROSCIENCE To NEUROLOGY. Elsevier Inc. 2005. p. 387-403 https://doi.org/10.1016/B978-012738903-5/50024-2
Chichung Lie, D. ; Colamarino, Sophia A. ; Song, Hongjun ; Gage, Fred H. / Harnessing Endogenous Stem Cells for Central Nervous System Repair. From NEUROSCIENCE To NEUROLOGY. Elsevier Inc., 2005. pp. 387-403
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