Data sharing and integration between clinical research data management system (CDMS) and electronic health record (EHR) system remains a challenging issue. To deal with the challenge, there is emerging interest in utilizing the Detailed Clinical Modeling (DCM) approach across a variety of contexts. The Intermountain Healthcare Clinical Element Models (CEMs) have been adopted by the Office of the National Coordinator (ONC) awarded SHARPn project for normalizing patient data from the electronic medical records (EMRs). The objective of the present study is to describe our preliminary efforts on harmonization of the SHARPn CEMs with CDISC (Clinical Data Interchange Standards Consortium) clinical study data standards. We were focused on three generic domains: Demographics, Lab Tests and Medications. We performed a panel review on each data element extracted from the CDISC templates and SHARPn CEMs. We have identified a set of data elements that are common to the context of both clinical research and secondary use and discussed outstanding harmonization issues. We consider that the outcomes would be useful for defining new requirements for the DCM modeling community and ultimately facilitating the semantic interoperability between systems for both clinical research and secondary use.