Haplotype analysis of the SDF-1 (CXCL12) gene in a longitudinal HIV-1/AIDS cohort study

W. S. Modi, K. Scott, J. J. Goedert, D. Vlahov, S. Buchbinder, R. Detels, S. Donfield, S. J. O'Brien, C. Winkler

Research output: Contribution to journalArticlepeer-review

Abstract

The stromal-derived factor-1 (SDF-1) chemokine gene encodes the only natural ligand for CXCR4, the coreceptor for the pathogenic X4 HIV-1 strains. A single-nucleotide polymorphism (SNP) in the 3′ untranslated region (SDF1-3′ A = rs1801157) of SDF-1 was reported to be protective against infection and progression in some, but not other, epidemiological studies. To identify additional alleles that may influence HIV-1 infection and progression to AIDS, nine SNPs (including rs1801157) spanning 20.2kb in and around the SDF-1 gene were genotyped in over 3000 African American (AA) and European American (EA) participants enrolled in five longitudinal HIV-1/AIDS natural cohort studies. Six or five haplotypes were present at frequencies greater than 5% in AA or EA, respectively. Six of the nine SNPs occur on only one common haplotype (>5%), while the remaining three SNPs were found on multiple haplotypes, suggesting a complex history of recombination. Among EA, rs754618 was associated with an increased risk of infection (OR = 1.50, P = 0.03), while rs1801157 (= SDF1-3′ A) was associated with protection against infection (OR = 0.63, P = 0.01). In the MACS cohort, rs1801157 was associated with AIDS-87 (RH = 0.31, P = 0.02) and with death (RH = 0.18, P = 0.02). Significant associations to a single disease outcome were found for two SNPs and one haplotype in AA.

Original languageEnglish (US)
Pages (from-to)691-698
Number of pages8
JournalGenes and immunity
Volume6
Issue number8
DOIs
StatePublished - Dec 2005
Externally publishedYes

Keywords

  • AIDS
  • Epidemiology
  • HIV-1
  • Haplotypes
  • SDF-1 chemokine

ASJC Scopus subject areas

  • Immunology
  • Genetics
  • Genetics(clinical)

Fingerprint

Dive into the research topics of 'Haplotype analysis of the SDF-1 (CXCL12) gene in a longitudinal HIV-1/AIDS cohort study'. Together they form a unique fingerprint.

Cite this