Haploidentical Bone Marrow Transplantation with Post-Transplant Cyclophosphamide Using Non–First-Degree Related Donors

Hany Elmariah, Yvette L. Kasamon, Marianna Zahurak, Karen W. Macfarlane, Noah Tucker, Gary L. Rosner, Javier Bolaños-Meade, Ephraim J. Fuchs, Nina Wagner-Johnston, Lode J. Swinnen, Carol Ann Huff, William H. Matsui, Douglas E. Gladstone, Shannon R. McCurdy, Ivan Borrello, Christian B. Gocke, Satish P Shanbhag, Kenneth R. Cooke, Syed Abbas Ali, Robert A. BrodskyAmy E. DeZern, Leo Luznik, Richard J. Jones, Richard F. Ambinder

Research output: Contribution to journalArticlepeer-review

Abstract

Outcomes of nonmyeloablative (NMA) haploidentical (haplo) blood or marrow transplant (BMT) with post-transplantation cyclophosphamide (PTCy) using non–first-degree relatives are unknown. We evaluated 33 consecutive adult patients (median age, 56 years) with hematologic malignancies who underwent NMA haplo T cell–replete BMT with PTCy at Johns Hopkins using second- or third-degree related donors. Donors consisted of 10 nieces (30%), 9 nephews (27%), 7 first cousins (21%), 5 grandchildren (15%), and 2 uncles (6%). Thirty-one patients (94%) reached full donor chimerism by day 60. The estimated cumulative incidence (CuI) of grades II to IV acute graft-versus-host disease (aGVHD) at day 180 was 24% (90% confidence interval [CI], 9% to 38%). Only 1 patient experienced grades III to IV aGVHD. At 1 year the CuI of chronic GVHD was 10% (90% CI, 0% to 21%). The CuI of nonrelapse mortality at 1 year was 5% (90% CI, 0% to 14%). At 1 year the probability of relapse was 31% (90% CI, 12% to 49%), progression-free survival 64% (90% CI, 48% to 86%), and overall survival 95% (90% CI, 87% to 100%). The 1-year probability of GVHD-free, relapse-free survival was 57% (90% CI, 41% to 79%). NMA haplo BMT with PTCy from non–first-degree relatives is an acceptably safe and effective alternative donor platform, with results similar to those seen with first-degree relatives.

Original languageEnglish (US)
Pages (from-to)1099-1102
Number of pages4
JournalBiology of Blood and Marrow Transplantation
Volume24
Issue number5
DOIs
StatePublished - May 2018

Keywords

  • Bone marrow transplant
  • Haploidentical
  • Post-transplant cyclophosphamide
  • Second-degree relatives

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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