HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice

Fabien Bertaux, Alan H. Sharp, Christopher A. Ross, Hans Lehrach, Gillian P. Bates, Erich Wanker

Research output: Contribution to journalArticle

Abstract

HAP1 (huntingtin associated protein) has previously been found to interact with huntingtin (htt) in a glutamine length dependent manner and has been proposed to play a role in the cell specific neurodegeneration observed in Huntington's disease (HD). We have isolated mouse HAP1 (hap1) and have shown that expression is not enriched in areas specifically affected in HD. We have used the yeast two hybrid system to demonstrate that htt amino acids 171-230 are necessary for the hap1-htt binding and that hap1 does not interact with the transgene exon 1 protein in a transgenic model of HD.

Original languageEnglish (US)
Pages (from-to)229-232
Number of pages4
JournalFEBS Letters
Volume426
Issue number2
DOIs
StatePublished - Apr 17 1998

Keywords

  • HAP1
  • Huntington's disease
  • Polyglutamine
  • Triplet repeat

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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