Halothane alters the oxygen consumption-oxygen delivery relationship compared with conscious state

P. Rock; C. Beattie; A. W. Kimball; D. P. Nyhan; B. B. Chen; D. M. Fehr; S. A. Derrer; S. D. Parker; P. A. Murray

doi:10.1097/00000542-199012000-00017

Halothane alters the oxygen consumption-oxygen delivery relationship compared with conscious state

P. Rock, C. Beattie, A. W. Kimball, D. P. Nyhan, B. B. Chen, D. M. Fehr, S. A. Derrer, S. D. Parker, P. A. Murray

School of Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The authors' objectives were as follows: 1) to characterize for the first time the relationship between whole body O₂ delivery (Ḋ(O₂)) and O₂ consumption (V̇(O₂)) in adult conscious dogs; and 2) to assess the effects of the inhalational anesthetic, halothane, on that relationship. Ḋ(O₂) was varied over a wide range in chronically instrumented dogs by gradual inflation and deflation of a hydraulic occluder implanted around the thoracic inferior vena cava to alter venous return and cardiac output. V̇(O₂) was measured at different values of Ḋ(O₂) in dogs in the fully conscious state and again during halothane anesthesia. A 'binning' technique indicated that halothane decreased V̇(O₂) (P < 0.01) at any given value of Ḋ(O₂) over a broad range of V̇(O₂). A two-line piecewise linear regression analysis technique indicated that halothane decreased (P < 0.01) the critical O₂ delivery (COD) from 20 ± 3 to 10 ± 1 ml·kg^-1·min^-1 and increased (P < 0.01) O₂ extraction at COD from 31 ± 3 to 40 ± 2%. However, the Ḋ(O₂)-V̇(O₂) plots measured in both conscious and halothane-anesthetized dogs did not exhibit a discrete discontinuity but rather were closely fit (correlation coefficient = 0.98) by an exponential equation of the following form: O₂ extraction = B1·(1 - exp (-Ḋ(O₂)/B2))/Ḋ(O₂), where B1 is the delivery-independent estimate of V̇(O₂) and B2 is the 'delivery constant', i.e., the Ḋ(O₂) associated with a V̇(O₂) equal to 63% of B1. Halothane decreased B1 (P < 0.01) from 5.3 ± 0.1 to 3.9 ± 0.1 ml·kg^-1·min^-1 and decreased B2 (P < 0.01) from 5.6 ± 0.3 to 3.6 ± 0.3 ml·kg^-1·min^-1 compared with that measured in conscious dogs. Thus, compared with the conscious state, halothane anesthesia alters the fundamental relationship between Ḋ(O₂) and V̇(O₂) and may have a beneficial effect on tissue oxygenation at low values of Ḋ(O₂).

Original language	English (US)
Pages (from-to)	1186-1197
Number of pages	12
Journal	Anesthesiology
Volume	73
Issue number	6
DOIs	https://doi.org/10.1097/00000542-199012000-00017
State	Published - 1990

Keywords

anesthesia
blood pressure
cardiac output
chronic instrumentation
critical oxygen delivery

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

Access to Document

10.1097/00000542-199012000-00017

Cite this

@article{e04f3a12d3a04924b15e5400b3447a79,

title = "Halothane alters the oxygen consumption-oxygen delivery relationship compared with conscious state",

abstract = "The authors' objectives were as follows: 1) to characterize for the first time the relationship between whole body O2 delivery (Ḋ(O2)) and O2 consumption ({\.V}(O2)) in adult conscious dogs; and 2) to assess the effects of the inhalational anesthetic, halothane, on that relationship. Ḋ(O2) was varied over a wide range in chronically instrumented dogs by gradual inflation and deflation of a hydraulic occluder implanted around the thoracic inferior vena cava to alter venous return and cardiac output. {\.V}(O2) was measured at different values of Ḋ(O2) in dogs in the fully conscious state and again during halothane anesthesia. A 'binning' technique indicated that halothane decreased {\.V}(O2) (P < 0.01) at any given value of Ḋ(O2) over a broad range of {\.V}(O2). A two-line piecewise linear regression analysis technique indicated that halothane decreased (P < 0.01) the critical O2 delivery (COD) from 20 ± 3 to 10 ± 1 ml·kg-1·min-1 and increased (P < 0.01) O2 extraction at COD from 31 ± 3 to 40 ± 2%. However, the Ḋ(O2)-{\.V}(O2) plots measured in both conscious and halothane-anesthetized dogs did not exhibit a discrete discontinuity but rather were closely fit (correlation coefficient = 0.98) by an exponential equation of the following form: O2 extraction = B1·(1 - exp (-Ḋ(O2)/B2))/Ḋ(O2), where B1 is the delivery-independent estimate of {\.V}(O2) and B2 is the 'delivery constant', i.e., the Ḋ(O2) associated with a {\.V}(O2) equal to 63% of B1. Halothane decreased B1 (P < 0.01) from 5.3 ± 0.1 to 3.9 ± 0.1 ml·kg-1·min-1 and decreased B2 (P < 0.01) from 5.6 ± 0.3 to 3.6 ± 0.3 ml·kg-1·min-1 compared with that measured in conscious dogs. Thus, compared with the conscious state, halothane anesthesia alters the fundamental relationship between Ḋ(O2) and {\.V}(O2) and may have a beneficial effect on tissue oxygenation at low values of Ḋ(O2).",

keywords = "anesthesia, blood pressure, cardiac output, chronic instrumentation, critical oxygen delivery",

author = "P. Rock and C. Beattie and Kimball, {A. W.} and Nyhan, {D. P.} and Chen, {B. B.} and Fehr, {D. M.} and Derrer, {S. A.} and Parker, {S. D.} and Murray, {P. A.}",

year = "1990",

doi = "10.1097/00000542-199012000-00017",

language = "English (US)",

volume = "73",

pages = "1186--1197",

journal = "Anesthesiology",

issn = "0003-3022",

publisher = "Lippincott Williams and Wilkins",

number = "6",

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T1 - Halothane alters the oxygen consumption-oxygen delivery relationship compared with conscious state

AU - Rock, P.

AU - Beattie, C.

AU - Kimball, A. W.

AU - Nyhan, D. P.

AU - Chen, B. B.

AU - Fehr, D. M.

AU - Derrer, S. A.

AU - Parker, S. D.

AU - Murray, P. A.

PY - 1990

Y1 - 1990

N2 - The authors' objectives were as follows: 1) to characterize for the first time the relationship between whole body O2 delivery (Ḋ(O2)) and O2 consumption (V̇(O2)) in adult conscious dogs; and 2) to assess the effects of the inhalational anesthetic, halothane, on that relationship. Ḋ(O2) was varied over a wide range in chronically instrumented dogs by gradual inflation and deflation of a hydraulic occluder implanted around the thoracic inferior vena cava to alter venous return and cardiac output. V̇(O2) was measured at different values of Ḋ(O2) in dogs in the fully conscious state and again during halothane anesthesia. A 'binning' technique indicated that halothane decreased V̇(O2) (P < 0.01) at any given value of Ḋ(O2) over a broad range of V̇(O2). A two-line piecewise linear regression analysis technique indicated that halothane decreased (P < 0.01) the critical O2 delivery (COD) from 20 ± 3 to 10 ± 1 ml·kg-1·min-1 and increased (P < 0.01) O2 extraction at COD from 31 ± 3 to 40 ± 2%. However, the Ḋ(O2)-V̇(O2) plots measured in both conscious and halothane-anesthetized dogs did not exhibit a discrete discontinuity but rather were closely fit (correlation coefficient = 0.98) by an exponential equation of the following form: O2 extraction = B1·(1 - exp (-Ḋ(O2)/B2))/Ḋ(O2), where B1 is the delivery-independent estimate of V̇(O2) and B2 is the 'delivery constant', i.e., the Ḋ(O2) associated with a V̇(O2) equal to 63% of B1. Halothane decreased B1 (P < 0.01) from 5.3 ± 0.1 to 3.9 ± 0.1 ml·kg-1·min-1 and decreased B2 (P < 0.01) from 5.6 ± 0.3 to 3.6 ± 0.3 ml·kg-1·min-1 compared with that measured in conscious dogs. Thus, compared with the conscious state, halothane anesthesia alters the fundamental relationship between Ḋ(O2) and V̇(O2) and may have a beneficial effect on tissue oxygenation at low values of Ḋ(O2).

AB - The authors' objectives were as follows: 1) to characterize for the first time the relationship between whole body O2 delivery (Ḋ(O2)) and O2 consumption (V̇(O2)) in adult conscious dogs; and 2) to assess the effects of the inhalational anesthetic, halothane, on that relationship. Ḋ(O2) was varied over a wide range in chronically instrumented dogs by gradual inflation and deflation of a hydraulic occluder implanted around the thoracic inferior vena cava to alter venous return and cardiac output. V̇(O2) was measured at different values of Ḋ(O2) in dogs in the fully conscious state and again during halothane anesthesia. A 'binning' technique indicated that halothane decreased V̇(O2) (P < 0.01) at any given value of Ḋ(O2) over a broad range of V̇(O2). A two-line piecewise linear regression analysis technique indicated that halothane decreased (P < 0.01) the critical O2 delivery (COD) from 20 ± 3 to 10 ± 1 ml·kg-1·min-1 and increased (P < 0.01) O2 extraction at COD from 31 ± 3 to 40 ± 2%. However, the Ḋ(O2)-V̇(O2) plots measured in both conscious and halothane-anesthetized dogs did not exhibit a discrete discontinuity but rather were closely fit (correlation coefficient = 0.98) by an exponential equation of the following form: O2 extraction = B1·(1 - exp (-Ḋ(O2)/B2))/Ḋ(O2), where B1 is the delivery-independent estimate of V̇(O2) and B2 is the 'delivery constant', i.e., the Ḋ(O2) associated with a V̇(O2) equal to 63% of B1. Halothane decreased B1 (P < 0.01) from 5.3 ± 0.1 to 3.9 ± 0.1 ml·kg-1·min-1 and decreased B2 (P < 0.01) from 5.6 ± 0.3 to 3.6 ± 0.3 ml·kg-1·min-1 compared with that measured in conscious dogs. Thus, compared with the conscious state, halothane anesthesia alters the fundamental relationship between Ḋ(O2) and V̇(O2) and may have a beneficial effect on tissue oxygenation at low values of Ḋ(O2).

KW - anesthesia

KW - blood pressure

KW - cardiac output

KW - chronic instrumentation

KW - critical oxygen delivery

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Halothane alters the oxygen consumption-oxygen delivery relationship compared with conscious state

Abstract

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