Haloperidol-induced changes in blink rates correlate with changes in BPRS score

C. N. Karson, L. B. Bigelow, Joel Kleinman, Daniel Weinberger, R. J. Wyatt

Research output: Contribution to journalArticle


Spontaneous eye blink rates, psychiatric symptoms and response to neuroleptic medication may all be mediated by dopamine. Fixed doses of haloperidol, a dopamine blocking agent, were administered for six weeks to 17 chronic schizophrenic patients who had been previously withdrawn from all medications. The change in blink rates caused by haloperidol corresponded to a change in the thought disturbance syndrome which measures positive symptoms (r = .48, P < .05). The relationship was particularly clear in patients with normal cerebral ventricles (r = .74, P < .01).

Original languageEnglish (US)
Pages (from-to)503-507
Number of pages5
JournalBritish Journal of Psychiatry
Issue number5
Publication statusPublished - 1982
Externally publishedYes


ASJC Scopus subject areas

  • Neuroscience(all)
  • Psychiatry and Mental health

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