Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals

George Ricaurte, G. Bryan, L. Strauss, L. Seiden, C. Schuster

Research output: Contribution to journalArticle

Abstract

(±)-3,4-Methylenedioxyamphetamine (MDA), an amphetamine analog with hallucinogenic activity, produced selective long-lasting reductions in the level of serotonin, the number of serotonin uptake sites, and the concentration of 5-hydroxyindoleacetic acid in rat brain. Morphological studies suggested that these neurochemical deficits were due to serotonin nerve terminal degeneration. These results show that MDA has toxic activity for serotonin neurons in rats and raise the question of whether exposure to MDA and related hallucinogenic amphetamines can produce serotonin neurotoxicity in the human brain.

Original languageEnglish (US)
Pages (from-to)986-988
Number of pages3
JournalScience
Volume229
Issue number4717
StatePublished - 1985
Externally publishedYes

Fingerprint

Amphetamine
Serotonin
Brain
3,4-Methylenedioxyamphetamine
Amphetamines
Nerve Degeneration
Hydroxyindoleacetic Acid
Poisons
Neurons

ASJC Scopus subject areas

  • General

Cite this

Ricaurte, G., Bryan, G., Strauss, L., Seiden, L., & Schuster, C. (1985). Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals. Science, 229(4717), 986-988.

Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals. / Ricaurte, George; Bryan, G.; Strauss, L.; Seiden, L.; Schuster, C.

In: Science, Vol. 229, No. 4717, 1985, p. 986-988.

Research output: Contribution to journalArticle

Ricaurte, G, Bryan, G, Strauss, L, Seiden, L & Schuster, C 1985, 'Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals', Science, vol. 229, no. 4717, pp. 986-988.
Ricaurte G, Bryan G, Strauss L, Seiden L, Schuster C. Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals. Science. 1985;229(4717):986-988.
Ricaurte, George ; Bryan, G. ; Strauss, L. ; Seiden, L. ; Schuster, C. / Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals. In: Science. 1985 ; Vol. 229, No. 4717. pp. 986-988.
@article{01a4b648e8c04de3bdf785af3abab82d,
title = "Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals",
abstract = "(±)-3,4-Methylenedioxyamphetamine (MDA), an amphetamine analog with hallucinogenic activity, produced selective long-lasting reductions in the level of serotonin, the number of serotonin uptake sites, and the concentration of 5-hydroxyindoleacetic acid in rat brain. Morphological studies suggested that these neurochemical deficits were due to serotonin nerve terminal degeneration. These results show that MDA has toxic activity for serotonin neurons in rats and raise the question of whether exposure to MDA and related hallucinogenic amphetamines can produce serotonin neurotoxicity in the human brain.",
author = "George Ricaurte and G. Bryan and L. Strauss and L. Seiden and C. Schuster",
year = "1985",
language = "English (US)",
volume = "229",
pages = "986--988",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4717",

}

TY - JOUR

T1 - Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals

AU - Ricaurte, George

AU - Bryan, G.

AU - Strauss, L.

AU - Seiden, L.

AU - Schuster, C.

PY - 1985

Y1 - 1985

N2 - (±)-3,4-Methylenedioxyamphetamine (MDA), an amphetamine analog with hallucinogenic activity, produced selective long-lasting reductions in the level of serotonin, the number of serotonin uptake sites, and the concentration of 5-hydroxyindoleacetic acid in rat brain. Morphological studies suggested that these neurochemical deficits were due to serotonin nerve terminal degeneration. These results show that MDA has toxic activity for serotonin neurons in rats and raise the question of whether exposure to MDA and related hallucinogenic amphetamines can produce serotonin neurotoxicity in the human brain.

AB - (±)-3,4-Methylenedioxyamphetamine (MDA), an amphetamine analog with hallucinogenic activity, produced selective long-lasting reductions in the level of serotonin, the number of serotonin uptake sites, and the concentration of 5-hydroxyindoleacetic acid in rat brain. Morphological studies suggested that these neurochemical deficits were due to serotonin nerve terminal degeneration. These results show that MDA has toxic activity for serotonin neurons in rats and raise the question of whether exposure to MDA and related hallucinogenic amphetamines can produce serotonin neurotoxicity in the human brain.

UR - http://www.scopus.com/inward/record.url?scp=0022357597&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022357597&partnerID=8YFLogxK

M3 - Article

C2 - 4023719

AN - SCOPUS:0022357597

VL - 229

SP - 986

EP - 988

JO - Science

JF - Science

SN - 0036-8075

IS - 4717

ER -