Hairless triggers reactivation of hair growth by promoting Wnt signaling

Gerard M.J. Beaudoin, Jeanne M. Sisk, Pierre A. Coulombe, Catherine C. Thompson

Research output: Contribution to journalArticlepeer-review

Abstract

The mammalian hair cycle involves periodic regeneration of a tiny organ, the hair follicle, through a stem-cell-mediated process. The Hairless (Hr) gene encodes a nuclear receptor corepressor (HR) that is essential for hair follicle regeneration, but its role in this process is unknown. Here, we demonstrate that transgenic expression of HR in progenitor keratinocytes rescues follicle regeneration in Hr-/- mice. We show that expression of Wise, a modulator of Wnt signaling, is repressed by HR in these cells, coincident with the timing of follicle regeneration. This work links HR and Wnt function, providing a model in which HR regulates the precise timing of Wnt signaling required for hair follicle regeneration.

Original languageEnglish (US)
Pages (from-to)14653-14658
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume102
Issue number41
DOIs
StatePublished - Oct 11 2005

Keywords

  • Corepressor
  • Nuclear receptor
  • Skin

ASJC Scopus subject areas

  • General

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