TY - JOUR
T1 - Hair cell afferent synapses
AU - Glowatzki, Elisabeth
AU - Grant, Lisa
AU - Fuchs, Paul
N1 - Funding Information:
Work in the authors’ laboratories was supported by the National Institute on Deafness and Other Communication Disorders grants DC006476 to EG, DC000276 to PAF, and P30 DC005211.
PY - 2008/8
Y1 - 2008/8
N2 - This review will cover advances in the study of hair cell afferent synaptic function occurring between 2005 and 2008. During this time, capacitance measurements of vesicular fusion have continued to be refined, optical methods have added insights regarding vesicle trafficking, and paired intracellular recordings have established the transfer function of the afferent synapse at high resolution. Further, genes have been identified with forms of deafness known as auditory neuropathy, and their role in afferent signaling explored in mouse models. With these advances, our view of the hair cell afferent synapse has continued to be refined, and surprising properties have been revealed that emphasize the unique role of this structure in neural function.
AB - This review will cover advances in the study of hair cell afferent synaptic function occurring between 2005 and 2008. During this time, capacitance measurements of vesicular fusion have continued to be refined, optical methods have added insights regarding vesicle trafficking, and paired intracellular recordings have established the transfer function of the afferent synapse at high resolution. Further, genes have been identified with forms of deafness known as auditory neuropathy, and their role in afferent signaling explored in mouse models. With these advances, our view of the hair cell afferent synapse has continued to be refined, and surprising properties have been revealed that emphasize the unique role of this structure in neural function.
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U2 - 10.1016/j.conb.2008.09.006
DO - 10.1016/j.conb.2008.09.006
M3 - Review article
C2 - 18824101
AN - SCOPUS:55249122406
SN - 0959-4388
VL - 18
SP - 389
EP - 395
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 4
ER -